Studies on the Synthesis and Biological Activity of 1-Alkyl(or Aryl)- 5-Substituted Amino-4-(N-Alkyl carbamoyl)pyrazole

Abstract

Abstract: In order to look for biologically active heterocyclic compounds, pyrazolo[3,4-d]-1 ,3-oxazin-6-ones(Ⅱ) were reacted with primary amines, l-alkyl(or aryl)-5-benzoylamino-4-(N-alkyl carbamoyDpyrazole (Ⅱ) were obtained.By the reduction of Ⅱ, it was found for the first time that only one of the two amide groups in compound Ⅱ was reduced selectively to give 1-alkyl (or aryl)-5-substituted amino-4-(N-alkyl carbamoyl) pyrazole (Ⅲ).Twenty three new compounds were prepared and identified by ¹H NMR,¹³C NMI,IRand MS.The preliminary biological activities of the products indicate that some of them possess antitumor and pesticidal activities.

Key words: 1-Alkyl-5-substituted amino-4-(N-alkyl carbamoyl) pyrazole, Selective reduction, Biological activity

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CHEN Ru-yu, WANG Jian-wu . Studies on the Synthesis and Biological Activity of 1-Alkyl(or Aryl)- 5-Substituted Amino-4-(N-Alkyl carbamoyl)pyrazole[J]. Chem. J. Chinese Universities, 1992, 13(1): 52.

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Studies on the Synthesis and Biological Activity of 1-Alkyl(or Aryl)- 5-Substituted Amino-4-(N-Alkyl carbamoyl)pyrazole

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