Chem. J. Chinese Universities ›› 1991, Vol. 12 ›› Issue (6): 771.

• Articles • Previous Articles     Next Articles

Synthesis of (4S, 5R)-5-Hydroxy-4-Decanolide, the Autoregulator of Blood Cancer from Streptomyces Griseus

Lu Zhong-e, Sun Da-qins, Chen Ke-qian, Xu Hai-jian   

  1. Department of Chemistry, Suzhou University, Suzhou, 215006
  • Received:1990-06-22 Online:1991-06-24 Published:1991-06-24

Abstract: (4S, 5R)-5-hydroxy-4-decanolide 1, the proposed autoregulator of blood cancer from Streptomyces griseus was synthesized from an allyl alcohol 2, employing the Sharpless kinetic resolution and the reaction of diethyl malonate with epoxy compound 4 as two key steps.

Key words: Autoregulator of blood cancer, Sharpless kinetic resolution, Decanolide

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