Synthesis of 1-Acyl Benzoimidazole and 3-Acyl-2-Thiothiazolidone Derivatives

Abstract

Abstract: The 14 new derivatives of 1-acylbenzoimidazole and 3-acyl-2-thiothiazolidone have been prepared by the reaction, of benzoimidazole or 3-thiothiazolidone with 4-alkyl-4-cyano-4-phenyl-bu-tanoyl chloride in the presence of organic bases such as triethylamine, pyridine or benzoimidazole itself, the acyl chlorides are not purified from the reaction of the corresponding acid and thionyl chloride. It has been shown that all compounds prepared have definite fungicidal effects from the results of ten pathogens test.

Key words: Benzyl cyanide, Benzoimidazole, Thiothiazolidone, Biological activity

TrendMD:

Wang Duhu, Wang Dazuo. Synthesis of 1-Acyl Benzoimidazole and 3-Acyl-2-Thiothiazolidone Derivatives[J]. Chem. J. Chinese Universities, 1990, 11(7): 756.

[1]	WEI Simin,WANG Yinghui,TANG Zhishu,SU Rui,HU Jinhang,GUO Hui,LI Chen,JIANG Jintao,SONG Zhongxing. Novel Biosynthesis Method of Silver Nanoparticle by UV Radiation of Cornus Officinalis Aqueous Extract and Biological Activities ^† [J]. Chem. J. Chinese Universities, 2020, 41(6): 1391.
[2]	SHI Yujun, FANG Yuan, LI Yang, CHEN Jia, LI Gang, WANG Qingmin, DAI Hong. Synthesis and Biological Activities of Novel Cyanoacrylate Derivatives Carrying 5-Arylisoxazole Group^† [J]. Chem. J. Chinese Universities, 2017, 38(3): 421.
[3]	ZHANG Lingzhi, JIANG Minrui, WEI Ping, ZHU Qihua, GONG Guoqing, BIAN Xueguo, XU Yungen. Synthesis, Metabolic Stability and Biological Activity in vivo of Lorcaserin Derivatives^† [J]. Chem. J. Chinese Universities, 2017, 38(10): 1778.
[4]	ZHANG Yan, WANG Baolei, ZHAN Yizhou, ZHANG Liyuan, LI Yonghong, LI Zhengming. Synthesis and Biological Activities of Novel 5-(Pyridine-3-yl)-1,2,4-triazole Mannich Bases and Bis-Mannich Bases Containing Piperazine Moiety^† [J]. Chem. J. Chinese Universities, 2016, 37(6): 1100.
[5]	XU Gaofei, LIU Yanhong, YANG Xinling, WANG Daoquan, YUAN Dekai. Synthesis and Biological Activity of Novel Dicyano-containning Cyclopropane-1-carboxamides^† [J]. Chem. J. Chinese Universities, 2016, 37(3): 486.
[6]	QIN Yaoguo, ZHANG Jingpeng, SONG Dunlun, DUAN Hongxia, LING Yun, JIANG Biaobiao, WANG Di, YANG Xinling. Design, Synthesis and Biological Activity of Novel Aphid Alarm Pheromone Analogues Containing Isonicotinic Acid^† [J]. Chem. J. Chinese Universities, 2016, 37(11): 1977.
[7]	WANG Zijian, SUN Xiaohong, LIU Yuanfa, CHEN Bang, SHEN Shengqiang, JIN Ruyi, MA Haixia. Synthesis and Biological Activities of 1,2,4-Triazole Schiff Bases Containing Pyrazole Rings^† [J]. Chem. J. Chinese Universities, 2015, 36(7): 1315.
[8]	LI Xu, JIANG Jianhong, HAN Buxing, GU Huiwen, XIE Zhaofeng, CHEN Lan, XIAO Shengxiong, LI Chuanhua, LI Aitao, LI Xia, YAO Feihong, WANG Qun, LI Qiangguo. Synthesis and Biological Activities of o-Vanillin-histidine Schiff-base and Its Lanthanum Complex^† [J]. Chem. J. Chinese Universities, 2015, 36(5): 856.
[9]	SHEN Shengqiang, SUN Xiaohong, LIU Yuanfa, CHEN Bang, JIN Ruyi, MA Haixia. Synthesis and Biological Activity of 1,3,4-Oxadiazole Mannich Bases Containing Pyrimidine Rings^† [J]. Chem. J. Chinese Universities, 2014, 35(7): 1427.
[10]	LIU Shaohua, LING Yun, LI Hongyue, XU Dan, YANG Xinling. Design, Synthesis and Biological Activity of Novel Substituted Phenyl Oxazol Based Compounds^† [J]. Chem. J. Chinese Universities, 2014, 35(2): 281.
[11]	WANG Xin-Zhong, LIU Jian-Guo, TANG Yu-Feng, WANG Yu, ZHANG Pei-Biao, CHEN Xue-Si. Preparation of Controlled-release PLA Microspheres Loading Methylsulfonylmethane and Its Biological Activity [J]. Chem. J. Chinese Universities, 2013, 34(4): 984.
[12]	JI Xu, BIAN Liu-Jiao. Bioactive Change and Structural Change of Bacillus Amyloliquefaciens α-Amylases Induced by Ca²⁺ [J]. Chem. J. Chinese Universities, 2013, 34(11): 2517.
[13]	CHEN Zhe, KWONG Anna Ka-Yee, YANG Zhen-Jun, ZHANG Liang-Ren, LEE Hon Cheung, ZHANG Li-He. Synthesis and Biological Evaluation of Nicotinamide Adenine Dinucleotides Analogues as Inhibitors of CD38 [J]. Chem. J. Chinese Universities, 2012, 33(06): 1226.
[14]	XU Jun-Ying, DONG Wei-Li, XIONG Li-Xia, LI Zheng-Ming. Design, Synthesis and Biological Activities of Amides(Sulfonamides) Containing N-Pyridylpyrazole [J]. Chem. J. Chinese Universities, 2012, 33(02): 298.
[15]	LI Chen, YANG Zheng, SHE Meng-Yao, YIN Wen-Ting, LI Jian-Li*, ZHAO Gui-Fang, SHI Zhen. Recent Progress in Superoxide Dismutase Mimics [J]. Chem. J. Chinese Universities, 2011, 32(9): 2046.

Synthesis of 1-Acyl Benzoimidazole and 3-Acyl-2-Thiothiazolidone Derivatives

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments