Studies on Macrocyclic Diterpenoids (Ⅰ)——A New Approach to the Key Intermediate of Sarcophytol-B

Chem. J. Chinese Universities ›› 1990, Vol. 11 ›› Issue (11): 1218.

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Studies on Macrocyclic Diterpenoids (Ⅰ)——A New Approach to the Key Intermediate of Sarcophytol-B

Li Ying, Li Yulin

Institute of Organic Chemistry, Lanzhou University, Lanzhou, 730000

Received:1989-08-11 Online:1990-11-24 Published:1990-11-24

Abstract

Abstract: Ethyl (Z,E,E)-2-isopropyl-5,9,13-trimethyl-tetradeca-2, 4,8,12-tetraenoate(2), the key intermediate of Sarcophytol-B, has been synthesized by using geraniol as the starting material. The key step in the synthesis is Wittig coupling of farnesyltriphenylphosphonium bromide (8) with ethyl 2-oxo-3-methyl butyrate (3). (3) was prepared by Grignard reaction of ethyl oxalate with iso-propylmagnesium bromide.

Key words: Macrocyclic diterpenoids, Sarcophytol-B, (Z,E,E)-2-Isopropyl-5,9,13-trimethylte-tradeca-2,4,8,12-tetraenoate, Wittig reaction

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Li Ying, Li Yulin . Studies on Macrocyclic Diterpenoids (Ⅰ)——A New Approach to the Key Intermediate of Sarcophytol-B[J]. Chem. J. Chinese Universities, 1990, 11(11): 1218.

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Studies on Macrocyclic Diterpenoids (Ⅰ)——A New Approach to the Key Intermediate of Sarcophytol-B

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