CJCU

Chem. J. Chinese Universities ›› 1989, Vol. 10 ›› Issue (6): 664.

• Articles • Previous Articles     Next Articles

Measurement of Primary and Secondary Kinetic Deuterium Isotope Effects by Natural Abundance2H NMR(Ⅲ)—Application to the Hydrolysis of Some Grignard Reagents

Zhang Benli1, Li Guigen1, Gao Zhenheng1, Wu Jiazhen2   

  1. 1. Department of Chemistry, Nankai University, Tianjin;
    2. Institute of Biophysics, Academia Sinica, Beijing
  • Received:1987-11-12 Online:1989-06-24 Published:1989-06-24

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Abstract: We established a method of using natural-abundance 2HNMRfor the study of kinetic deuterium isotope effects (KDIE) which is based on the determination of site-specific isotope ratios of hydrogen in the molecules involved in the reaction. It was applied to the KDIEstudy of the hydrolysis of two Grignard reagents, benzylmagnesium chloride and phenylmagnesium bromide for which kH/kD= 1.52( ±0.03) and 1.50(±0.04), respectively.

Key words: Natural-abundance2H NMR, Isotope effects, Grignard reagent hydrolysis

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