Simultaneously Determining M ulticomponent of Acetaminophen Compound Tablets by Application of Partial Least Squares Method

Chem. J. Chinese Universities ›› 1989, Vol. 10 ›› Issue (10): 990.

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Simultaneously Determining M ulticomponent of Acetaminophen Compound Tablets by Application of Partial Least Squares Method

Wang Yiming¹, Luo Guoan¹, Wang Zhenpu², Zhou Guohua²

1. China Pharmaceutical University Nanjing;
2. Nanjing Institute of Chemical-Technology, Nanjing

Received:1988-01-20 Online:1989-10-24 Published:1989-10-24

Abstract

Abstract: The basic principle and computing method of the partial least squares method (PLS) applied to a multicompoent analysis were discussed.The optimum experimental condition of simultaneous UV-spectrophotometric determination of the contents of acetaminophen, aspirin and caffeine in acetaminophen compound tablets and the application of PLSin simultaneous multicomponent determination were studied.The average recovery ratio of the three components are 99.88±0.33%, 99.99± 0.14% and 99.92±1.24% (confidence 95%), respectively.No information has ever been available in the literature for the application of PLSto the pharmaceutical analysis.

Key words: Partial least squares method (PLS), Simultaneous determination of multicomponent by spectrophotometry, Acetaminophen compound tablets, Aspirin, Caffeine

TrendMD:

Wang Yiming, Luo Guoan, Wang Zhenpu, Zhou Guohua. Simultaneously Determining M ulticomponent of Acetaminophen Compound Tablets by Application of Partial Least Squares Method[J]. Chem. J. Chinese Universities, 1989, 10(10): 990.

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Simultaneously Determining M ulticomponent of Acetaminophen Compound Tablets by Application of Partial Least Squares Method

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