Chem. J. Chinese Universities ›› 1988, Vol. 9 ›› Issue (9): 912.

• Articles • Previous Articles     Next Articles

The Synthesis of Ethyl Cephalotaxinyl Oxalate and Its Application in the Synthesis of Cephalotaxus Ester Alkaloids

Liu Xingping, Wang Yongkeng, Li Shaobai, Pan Xinfu, Li Yulin, Huang Wenkui   

  1. Institute of Organic Chemistry, Lanzhou University, Lanzhou
  • Received:1987-03-13 Online:1988-09-24 Published:1988-09-24

Abstract: In this wrok, ethyl cephalotaxinyl oxalate was prepared by ester exchange and the synthesis of the key intermediate, α-keto-acetyl-cephalotaxine, was achieved by treating this oxalate with a Grignard reagent. This constitutes an efficient modification of previously reported mathods for the synthesis of cephalotaxus este ralkaloids.

Key words: Ethyl cephalotaxmyl oxalate, α-Keto-acetyl-cephaltaxme

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