CJCU

Chem. J. Chinese Universities ›› 1985, Vol. 6 ›› Issue (9): 843.

• Articles • Previous Articles     Next Articles

Removal of DNA Antibodies and DNA Immune Complexes from Mammal Blood with Spherical Carbonaceous Polymeric Adsorbent by Hemoperfusion

Yang Yan1, Li Naihong1, He Binglin1, Quan Wulie2, Cui Runhai2, Shao Xinhua2, Ye Fuhua2, Qian Shaocheng2, Song Jichang2   

  1. 1. Department of Chemistry, Nankai University, Institute of Molecular Biochemistry, Nankai University, Tianjin;
    2. Liter and Biliary Disease Research Unit. Hedong Hospital, Tianjin
  • Received:1984-06-16 Online:1985-09-24 Published:1985-09-24

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Abstract: DNAis complexed with tetrazolium cations (Blue tetrazolum, BT) and then mixed with collodion and finally adsorbed on the macroporous spherical carbonaceous polymeric adsorbents. The percentage of DNAthus immobilized is 98-98.5%. It was applied to animal hemoperfusion for the removal of the DNAantibodies and its immune complexes which were passively infused. After 10-20 minutes adsorption, a sharp reduction of DNAbinding was observed and the futuin (AFP) binding percentage only dropped slightly. The efficiency of the specific removal of DNAimmune complex was over 75% and only less than 10% unspecific adsorption occurred. Tt has a good stability and blood compatibility. Therefore, it might be applicable 1o clinical SLEtherapy.

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