Chem. J. Chinese Universities ›› 1985, Vol. 6 ›› Issue (2): 141.

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Study of SNAr Reaction Between Para-substituted Nitrobenzenes with Phenylacetonitrile

Hua Mei, Bai Tao, Li Qimin, Guan Zuowu   

  1. Pharmaceutical, Department, Beijing Medical, College, Beijing
  • Received:1983-03-16 Online:1985-02-24 Published:1985-02-24

Abstract: We have found that in reactions of para-chloro-, bromo-, Iodo- and carboxy-nitrobenzenes with phenylacetonitrile in the presence of EtOHand NaOHthe 5-substilulcd-3-phenyl-2,1 -isoxazoles arc obtained.However, there occur only SNAr reaction in the position para to nitrogroup for p-fluoro- and nitro-benzenes under various conditions.

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