Chem. J. Chinese Universities ›› 1985, Vol. 6 ›› Issue (10): 903.
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Zhang Lihe, Ma Lintai, Xu Chen, Dong Lingjiao, Wang Qi, Wang Xu
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Abstract: By using tosyl chloride or triphenyl phosphine/carbon tetrachloride as condensing reagents, 2'-tosyl c-AMPreacted with ROHor RNH2 to give nucleoside 3',5'-cyclic phosphotri-esters and phosphoramidates in 30-60% yield. Detosylation was carried out by using sodium naphthaline at -60℃+ in DMEin 70-90% yield. The stereoisomers of these compounds have been separated and the structures have been identified by 1H NMR, 13C NMR, 31P NMRand FDMS.
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Zhang Lihe, Ma Lintai, Xu Chen, Dong Lingjiao, Wang Qi, Wang Xu . The Syntheses of Derivatives of Nucleoside 3',5' -Cyclic Phosphate[J]. Chem. J. Chinese Universities, 1985, 6(10): 903.
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http://www.cjcu.jlu.edu.cn/EN/Y1985/V6/I10/903
