Abstract: 2-Phenyl-5-(4'-biphenyl)-oxazole and thirty one 2-substituted phe-nyl-5-(4'-biphenyl)-oxazoles are synthesized. Among them, thirty are new compounds. The M.P., λ_max of UV absorption spectra and fluorescence emission spectra, as well as laser properties of the compounds are given in tables. It is found that twenty three of the titled compounds are better than 2,5-diphenyl oxazole (PPO) in using as laser dye in near UVregion.Abrief discussion on the relation between the substituent effects and spectral properties of the compounds is given.