Chem. J. Chinese Universities ›› 2021, Vol. 42 ›› Issue (6): 1742.doi: 10.7503/cjcu20200905

• Organic Chemistry • Previous Articles     Next Articles

Chemical Constituents of New Steroidal Saponins from Allium chinense G. Don

YANG Yiran1, YAO Hua2, YAN Jianghong3, SUN Zhiheng1, ZHANG Yu1, FANG Xueqing4, LI Xuwen1, JIN Yon⁃Ri1()   

  1. 1.College of Chemistry,Jilin University,Changchun 130012,China
    2.China?Japan Union Hospital of Jilin University,Changchun 130033,China
    3.The First Clinical Hospital of Jilin Academy of Traditional Chinese Medicine,Changchun 130021,China
    4.School of Material Science,University of New South Wales,Sydney 2033,Australia
  • Received:2020-12-30 Online:2021-06-10 Published:2021-03-24
  • Contact: JIN Yon?Ri E-mail:jinyr@ jlu.edu.cn

Abstract:

Six new steroidal saponins were isolated from 98% ethanol extract of Allium chinense G. Don. Through spectral data as well as physical and chemical analysis, they were identified as 5α-cholano-22,16- lactone-3-O-β-D-glucopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→3)]-β-D-glucopyranosyl-(1→4)-β-D-galacopyranoside(1), 6-ketone-5α-cholano-22,16-lactone-3-O-β-D-6-xylopyranosyl-(1→4)-[α-L-arabinopyranosyl-(1→6)]-β-D-glucopyranoside(2), (25R)-26-O-β-D-glucopyranosyl-5α-furostane-3β,26-diol-3-O-β-D-glucopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→3)]-β-D-glucopyranosyl-(1→4)-β-D-galacopyranoside(3), (25R)-6-ketone-26-O-β-D-glucopyranosyl-5α-furostane-3β,22α,26-triol-3-O-α-L-xylopyranosyl-(1→4)-β-D-glucopyranoside(4), (25R)-6-ketone-5α-furostane-3β,22α,24β,26-tetraol-3-O-β-D-xylopyranosyl- (1→4)-[α-L-arabinopyranosyl-(1→6)]-β-D-glucopyranoside(5) and (25R)-5α-furostane-2α,3β,22α,26- tetraol-26-O-β-D-glucopyranoside(6). To the best of our knowledges, the sapogenin skeletons of compound 1 and compound 2 were isolated from natural products for the first time. The cell proliferation-toxicity test kit(CCK-8) was used to explore the PC12 cells hydrogen peroxide induced the protective effect of oxidative damage. The experimental results showed that compound 3 had a significant protective effect on cell oxidative damage induced by hydrogen peroxide.

? Supported by the Science and Technology Development Plan of Jilin Province, China(No.20200404138YY).

Key words: Allium chinense G. Don, Furostanol Saponin, Structure identification, Cell viability, Antioxidant capacity

CLC Number: 

TrendMD: