CJCU

Chem. J. Chinese Universities ›› 2013, Vol. 34 ›› Issue (2): 462.doi: 10.7503/cjcu20120639

• Polymer Chemistry • Previous Articles     Next Articles

Fabrication of Magnetic Protein Microcapsules by Sonochemical Method

WANG Chun-Lei1,2, YAN Jun-Tao1,2, ZHONG Shuang-Ling3, LI Zhan-Feng1, CUI Xue-Jun1, WANG Hong-Yan1   

  1. 1. College of Chemistry, Jilin University, Changchun 130012, China;
    2. Department of Chemistry and Environmental Engineering, Wuhan Polytechnic University, Wuhan 430023, China;
    3. College of Resources and Environment, Jilin Agricultural University, Changchun 130118, China
  • Received:2012-07-06 Online:2013-02-10 Published:2013-01-21

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Abstract:

Biocompatible magnetic protein microcapsules(MPMCs) were prepared by sonochemical method. Under high intensity ultrasonic treatment, the MPMCs were yielded at the interface between the oil liquids containing Fe3O4 nanoparticles and the protein solution within several minutes. Meanwhile, the hydrophobic drugs could be loaded into MPMCs directly via sonochemical method and the activities of proteins and drugs were not destroyed. The sonochemical technique is a very simple and cost-effective method to fabricate MPMCs as drug carriers. Such prepared MPMCs are very promising carriers for drug delivery systems and magnetic resonance imaging.

Key words: Protein microcapsule, Sonochemical method, Magnetic Fe3O4 nanoparticle, Targeted delivery

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