CJCU

Chem. J. Chinese Universities ›› 2013, Vol. 34 ›› Issue (2): 479.doi: 10.7503/cjcu20120522

• Polymer Chemistry • Previous Articles     Next Articles

Anticoagulant Properties on Carboxylated Graphene Oxide-Glutamic Acid Composite

GU Hao1,2, ZHOU Ning-Lin1,2,3, FAN Yun-Ting1,2, WANG Xiao-Dan1,2, LI Wen-Xiu1,2, SHEN Jian1,2,3   

  1. 1. Jiangsu Engineering Research Center for Biomedical Function Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China;
    2. Jiangsu Province Key Laboratory of Biofunctional Materials, Nanjing 210023, China;
    3. Jiangsu Province Technological Research Center for Interfacial Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China
  • Received:2012-05-29 Online:2013-02-10 Published:2013-01-21
  • Contact: ZHOU Ning-Lin E-mail:zhouninglin@njnu.edu.cn

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Abstract:

Anticoagulation properties of biomaterials are crucial for biomedical applications, especially for blood-contacting materials. Carboxylated graphene oxide complexes with L-glutamic acid was prepared. The complexes were characterized by FTIR, static contact angle(SCA), XRD and TG. The anticoagulation properties of complexes were evaluated by hemolysis test and recalcification time test. The results show that the L-glutamic acid has been coordinated on graphene oxide sheet layer. The plasma recalcification time were prolonged greatly as compared to whole blood. At lower concentrations, the hemolysis rates was less than 5%, which met the requirements of biomedical materials.

Key words: Carboxylated graphene oxide, L-Glutamic acid, Hemolysis test, Plasma recalcification time

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