Synthesis and Characterization of 4,4'-Di(p-aminophenylethynyl)-6,6'-bis[N,N-bis(ethoxycarbonylmethyl)amino methyl]-2,2'-bipyridine

doi:10.3969/j.issn.0251-0790.2012.07.017

Chem. J. Chinese Universities ›› 2012, Vol. 33 ›› Issue (07): 1462.doi: 10.3969/j.issn.0251-0790.2012.07.017

• Organic Chemistry • Previous Articles Next Articles

Synthesis and Characterization of 4,4'-Di(p-aminophenylethynyl)-6,6'-bis[N,N-bis(ethoxycarbonylmethyl)amino methyl]-2,2'-bipyridine

CAO Xi-Jie¹, XIE Wen-Bing², PAN Li-Hua², CHANG Yu², CUI Shan-Zi¹, ZHANG Hong-Jie², DANG Dan-Dan²

1. School of Chemical Engineering, Changchun University of Technology, Changchun 130012, China;
2. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China

Received:2011-12-15 Online:2012-07-10 Published:2012-07-10

Abstract

Abstract: In order to obtain a new solid phase time-resolved fluorescence immunoassay chelate, a new intermediate compound 4,4'-(p-aminophenylethynyl)-6,6'-bis[N,N-bis(ethoxycarbonylmethyl)amino methyl]-2,2'-bipyridine was prepared from 4,4'-dinitro-2,2'-bipyridine-6,6'-dimethyl bis(trifluoroacetate) by hydrolyzation, bromination, esterification and substitution. The structure of the compound was charactered by DSC, IR, ¹H NMR and HRMS. The compound was hydrolyzed in the solution of europium ion, forming a rare earth fluorescence chelate. The fluorescence spectrum of the chelate excited by an light source has peaks peculiar to the europium ion.

Key words: Solid phase time-resolved fluorescence immunoassay, Chelant, Intermediate, 4,4'-Di(p-aminophenylethynyl)-6,6'-bis[N,N-bis(ethoxycarbonylmethyl)amino methyl]-2,2'-bipyridine

CLC Number:

O621.3

TrendMD:

CAO Xi-Jie, XIE Wen-Bing, PAN Li-Hua, CHANG Yu, CUI Shan-Zi, ZHANG Hong-Jie, DANG Dan-Dan. Synthesis and Characterization of 4,4'-Di(p-aminophenylethynyl)-6,6'-bis[N,N-bis(ethoxycarbonylmethyl)amino methyl]-2,2'-bipyridine[J]. Chem. J. Chinese Universities, 2012, 33(07): 1462.

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Synthesis and Characterization of 4,4'-Di(p-aminophenylethynyl)-6,6'-bis[N,N-bis(ethoxycarbonylmethyl)amino methyl]-2,2'-bipyridine

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