Abstract: Marinopyrrole A, containing a novel structure with high halogenated bipyrrole, was found to exhibite antibacterrial activity against Methicillin-resistant staphylococcus aureus(MRSA), and against the human cancer cell(HCT-116). Owing to its low potency and high toxicity in vivo, the synthesis of Marinopyrrole A derivatives has become a new hot spot in natural products research.6-Flourobenzene of Marinopyrrole A was obtained by protection, addition step-by-step, oxidation, deprotection of the Ts group, chlorinated and deprotection of methyl group reactions from the starting material dialdehyde compound 1, and finally the yield was 13% after 9-step reactions. The structures of the compounds were confirmed by IR, ¹H NMR, ¹³C NMR and HRMS. Especially, the cyclic ether intermediate 3, necessary in original way, was no longer formed using the addition step-by-step and oxidation, and the total yield was improved. The examination approach provides a new synthetic way for the series Marinopyrrole A derivatives.

Key words: Marinopyrrole A derivative, Cyclic ether intermediate, Optimization of synthesis method