高等学校化学学报

高等学校化学学报

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新型含苯硼酸基团的两亲性共聚物微球的制备及其糖敏感性能

汤宇, 王瑱, 李朝兴   

  1. 南开大学化学学院高分子化学研究所, 天津 300071
  • 收稿日期:2007-01-25 修回日期:1900-01-01 出版日期:2007-08-10 发布日期:2007-08-10
  • 通讯作者: 李朝兴

Preparation of a Novel Amphiphilic Copolymer Microspheres with Phenylborate Moieties and Its Glucose-sensitive Properties

TANG Yu, WANG Zhen, LI Chao-Xing*   

  1. Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China
  • Received:2007-01-25 Revised:1900-01-01 Online:2007-08-10 Published:2007-08-10
  • Contact: LI Chao-Xing

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被引次数

13

摘要： 将3-丙烯酰胺基苯硼酸与马来酸酐改性β-环糊精反应, 合成了一种新型的共聚物, 并采用13C NMR, IR和UV-Vis等技术对共聚物的结构进行了表征. 利用SEM研究了聚合物在甲醇中的自组装形态. 通过在不同溶剂中溶解性能的研究, 探讨了共聚物与甲醇的络合机理以及自组装机理. 以格列奇特为模型药物, 研究了聚合物微球在不同环境下的振荡释放行为. 结果表明, 载药微球在30 min内对葡萄糖刺激迅速响应, 在葡萄糖浓度为3 g/L和无糖环境之间的振荡释放呈“开-关”式自调释放.

关键词: N-丙烯酰-3-氨基苯硼酸, β-环糊精, 药物释放, 自组装微球, 糖敏感性能

Abstract: A novel amphiphilic copolymer was prepared via copolymerization of N-acryloyl-3-aminophenylboronic acid with β-cyclodextrin containing maleic anhydride. The copolymer was characterized with 13C NMR, IR and UV-Vis techniques. The self-assembling morphology of the polymer microspheres in methanol was studied via SEM. The reaction mechanism of polymer with methanol and self-assembling mechanism were discussed with research on the solubility of the polymer in various solvents. Gliclazide as the model drug was loaded in the copolymer microspheres and the drug release oscillating behavior was studied. The results indicate that the microspheres respond to glucose rapidly in 30 min, and the microspheres exhibit self-regulated“on-off” release behavior between the solution with 3 g/L of the glucose and the medium without glucose.

Key words: N-acryloyl-3-aminophenylboronic acid, β-cyclodextrin, Drug release, Self assembling microsphere, Glucose sensitive property

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