高等学校化学学报

高等学校化学学报

• 研究简报 • 上一篇    下一篇

3-氧-11,12,13-三羟基桉烷-4-烯的简便全合成

关玉昆1,2, 房丽晶2, 唐志勇2, 李裕林2   

    1. 烟台大学药学院, 烟台 264005;
    2. 兰州大学功能有机分子化学国家重点实验室, 兰州 730000
  • 收稿日期:2006-10-17 修回日期:1900-01-01 出版日期:2007-07-10 发布日期:2007-07-10
  • 通讯作者: 关玉昆

Facile Total Synthesis of 3-Oxo-11,12,13-trihydroxyeudesm-4-ene

GUAN Yu-Kun1,2*, FANG Li-Jing2, TANG Zhi-Yong2, LI Yu-Lin2   

    1. School of Pharmacy, Yantai University, Yantai 264005, China;
    2. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China
  • Received:2006-10-17 Revised:1900-01-01 Online:2007-07-10 Published:2007-07-10
  • Contact: GUAN Yu-Kun

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被引次数

2

摘要：

报道了一种全合成3-氧-11,12,13-三羟基桉烷-4-烯(1)的简便方法. 对于该化合物及其衍生物的药理活性研究目前正在进行中.

关键词: 桉烷, 3-氧-11,12,13-三羟基桉烷-4-烯, 全合成, 倍半萜

Abstract:

3-Oxo-11,12,13-trihydroxyeudesm-4-ene(1) was a highly oxygenated natural eudesmane isolated from traditional herbal medicine with an antiphlogostic and spasmolytic activity. For the purpose of pharmacological activity research on natural product 1 and its derivatives, a facile total synthesis of compound 1 starting from (+)-dihydrocarvone(2) was completed in an overall yield of 24%. The structures of all intermediates and product 1 were confirmed via 1H NMR, 13C NMR, MS and IR techniques. The NMR data of compound 1 are in agreement with those of natural products.

Key words: Eudesmane, 3-Oxo-11,12,13-trihydroxyeudesm-4-ene, Total synthesis, Sesquiterpene

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