高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (2): 278.

• 论文 • 上一篇    下一篇

APA微胶囊扩散数学模型的改进

何洋, 谢玉冰, 王勇, 刘群, 马小军   

  1. 中国科学院大连化学物理研究所, 大连 116023
  • 收稿日期:1999-02-20 出版日期:2000-02-24 发布日期:2000-02-24
  • 通讯作者: 马小军(1958年出生),男,研究员,从事生物医学材料研究.
  • 基金资助:

    国家自然科学基金(批准号:29576264)资助

Improved Mathematical Model of APA Microcapsules

HE Yang, XIE Yu-Bing, WANG Yong, LIU Qun, MA Xiao-Jun   

  1. Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
  • Received:1999-02-20 Online:2000-02-24 Published:2000-02-24

摘要: 在膜阻力系数和膜内基质的分配系数两个新特性的基础上,重新建立了蛋白质在APA微胶囊体系上的扩散数学模型,该模型更为准确地反映出蛋白质在微胶囊上的扩散特性

关键词: APA微胶囊, 数学模型, 阻力系数, 分配系数

Abstract: It is essential to investigate the diffusion characteristics of alginate-polylysine-alginate(APA) microcapsule system for its broad applications. An advanced mathematical model for protein diffusion in APAmicrocapsules is established, which presents the resistance coefficient of microcapsule membrane and distribution coefficient in microcapsule matrix. These two parameters as the important basis of optimizing preparation and directing application of microcapsule are determined by the measurement of the protein concentration in the extracapsular solution. With assistance of mathmatical model, membrane diffusion characteristics affected by reaction time in membrane forming are analyzed: (1) microcapsule shows greater resistance constant and distribution constant to the diffusion of protein with greater molecular weight, (2) prologation reaction time results in increase in resistance constant and distribut constant of microcapsule.

Key words: APA microcapsule, Mathematical model, Resistance coefficient, Distribution coefficient

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