高等学校化学学报

高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (11): 1694.

• 研究简报 • 上一篇    下一篇

对-甲苯乙酮与芳香醛和芳香胺的Mannich反应

杨大成1, 章国林2, 杨宇3, 钟裕国3   

  1. 1. 西南师范大学化学化工学院, 重庆 400715;
    2. 浙江大学药学院, 杭州 310031;
    3. 华西医科大学药学院, 成都 610041
  • 收稿日期:1999-07-12 出版日期:2000-11-24 发布日期:2000-11-24
  • 通讯作者: 杨大成(1962年出生),男,博士研究生,副教授,主要从事有机反应及抗肿瘤药物研究.

The Mannich Reaction of 4-Methylacetophenone with Aromatic Aldehydes and Aromatic Amines

YANG Da-Cheng1, ZHANG Guo-Lin2, YANG Yu3, ZHONG Yu-Guo3   

  1. 1. School of Chemistry and Chemical Engineering, Southwest China Normal University, Chongqing 400715, China;
    2. School of Pharmacy, Zhejiang University, Hangzhou 310031;
    3. Schoolof Pharmacy, West China Universityof Medical Science, Chengdu 610041, China
  • Received:1999-07-12 Online:2000-11-24 Published:2000-11-24

PDF (PC)

被引次数

45

关键词: Mannich反应, Mannich碱, 芳香醛, 芳香胺, 对-甲苯乙酮

Abstract: In the presence of catalytical amount of concentrated hydrochloric acid, 4 methylacetophenone can react directly with benzaldehyde, 4-methylbenzaldehyde and some aromatic amines in ethanol solution at 26~32 ℃ to afford 1-(4-methylphenyl)-3 aryl-3-arylamino-1-propanones with 61%~96% yield. There are seven new compounds among the 17 substances prepared. The IR and 1H NMR spectra and elemental analyses of these Mannich bases are given and they are consistent with the structures of these compounds.

Key words: Mannich reaction, Mannich bases, Aromatic aldehydes, Aromatic amines, 4-Methylaceto-phenone

中图分类号: 

TrendMD: