关键词: 手性胺膦配体, 铱配合物, 芳香酮, 对映选择性氢化

Abstract: Enantioselective reduction of prochiral ketones with 2-propanol or formic acid catalyzed by chiral metal complexes has been developed as a synthetic method complementary to asymmetric hydrogenation in the past decade. However, these processes are necessary to be improved for practical use in organic synthesis because of low catalytic activity and insufficient enantioselectivity. In this paper, we wish to report an excellent catalytic system generated in situ from iridium complex IrCl(Ph3P)₃and chiral tetradentate di-aminodiphosphine ligand for asymmetric transfer hydrogenation of various aromatic ketones. For isobuty-rophenone transfer hydrogenation, the corresponding optically active alcohol was obtained in 93% yield and with up to 99% e. e. after 5h at 28℃. Propiophenone was a better substrate with respect to catalytic activity and enantioselectivity in the presence of base as a co-catalyst. The conversion of propiophenone reached 95. 8% and the turnover number as high as 3193h^-1. These results will provide a useful index for further designing practical chiral catalytic systems.

Key words: Chiral aminophosphine ligand, Iridium complex, Aromatic ketones, Enantioselective transfer hydrogenation