高等学校化学学报

高等学校化学学报

• 研究论文 • 上一篇    下一篇

大萼香茶菜中的新二萜化合物

石浩1, 何山1, 何兰2, 潘远江1   

    1. 浙江大学化学系, 杭州 310027;
    2. 北京师范大学化学系, 北京 100085
  • 收稿日期:2006-01-15 修回日期:1900-01-01 出版日期:2007-01-10 发布日期:2007-01-10
  • 通讯作者: 潘远江

New Diterpenoid Compound from Rabdosia macrocalyx

SHI Hao1, HE Shan1, HE Lan2, PAN Yuan-Jiang1   

    1. Department of Chemistry, Zhejiang University, Hangzhou 310027, China;
    2. Department of Chemistry, Beijing Normal University, Beijing 100085, China
  • Received:2006-01-15 Revised:1900-01-01 Online:2007-01-10 Published:2007-01-10
  • Contact: PAN Yuan-Jiang

PDF (PC)

被引次数

15

摘要： 报道从大萼香茶菜叶的乙醇提取物中分离得到一种新的二萜类化合物, 并命名为大萼香茶菜癸素(1). 其药理活性实验结果证明, 该化合物对体外培养的Hela细胞有较强的抑制作用.

关键词: 大萼香茶菜, B断裂贝壳杉烯, 大萼香茶菜癸素

Abstract:

On the basis of the investigation on natural product antitumor agents, a new diterpenoid named macrocalyxin J was isolated from the leaves of Rabdosia macrocalyx(Dunn) Hara by silica gel column chromatography. Based on IR, MS, 1H NMR, 13C NMR and 2D NMR spectroscopies, the structure of macrocalyxin J was determined as (1α,6β,11β,14α)-1,7∶6,20-diepoxy-6,11-dihydroxy-6,7-seco-ent-kaur-16-ene-7,15-dione-14-acetate. The antitumor activity of the compound was assayed by MTT method. Macrocalyxin J was shown to have a potency in vitro against the cultures of Hela cells.

Key words: Rabdosia macrocalyx, B-seco-ent-kaurene, Macrocalyxin J

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