高等学校化学学报

高等学校化学学报 ›› 2006, Vol. 27 ›› Issue (5): 939.doi:

• 研究论文 • 上一篇    下一篇

环糊精和α-萘乙酸包络物的核磁共振研究

彭敏, 孔旭新, 余亦华, 陈群   

  1. 华东师范大学物理系, 教育部光谱学与波谱学重点实验室, 上海 200062
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2006-05-10 发布日期:2006-05-10
  • 通讯作者: 陈群

NMR Study on Inclusion-complex of Cyclodextrin with α-Naphthylacetic Acid

PENG Min, KONG Xu-Xin, YU Yi-Hua, CHEN Qun*   

  1. Department of Physics, the Key Laboratory for Optics and Magnetic Resonance Spectroscopy of Education Ministry, East China Normal University, Shanghai 200062, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2006-05-10 Published:2006-05-10
  • Contact: CHEN Qun

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摘要：

利用溶液2D-ROESY谱,利用溶液2D-ROESY谱, 13C固体高分辨谱以及自扩散系数测量等核磁共振技术, 研究了环糊精(CD)和α-萘乙酸(α-NAA)的相互作用. 结果表明, α-CD和β-CD均能与α-NAA形成包络物, 但是由于尺寸更为匹配, β-CD与α-NAA体系的包络相互作用强度明显比α-CD和α-NAA体系的大; 通过测量 β-CD与α-NAA混合溶液中α-NAA的自扩散系数, 计算出包络物结合与解离的平衡常数, 以此为基础对β-CD/α-NAA 体系在实现α-NAA缓释方面的应用方式进行了探讨. 13C固体高分辨谱以及自扩散系数测量等核磁共振技术, 研究了环糊精(CD)和α-萘乙酸(α-NAA)的相互作用. 结果表明, α-CD和β-CD均能与α-NAA形成包络物, 但是由于尺寸更为匹配, β-CD与α-NAA体系的包络相互作用强度明显比α-CD和α-NAA体系的大; 通过测量 β-CD与α-NAA混合溶液中α-NAA的自扩散系数, 计算出包络物结合与解离的平衡常数, 以此为基础对β-CD/α-NAA 体系在实现α-NAA缓释方面的应用方式进行了探讨.

关键词: NMR; ROESY; 13C CP/MAS; 自扩散系数; 包络物

Abstract:

The interactions of α-naphthylacetic acid(α-NAA) with α-cyclodextrin(α-CD) and β-cyclodextrin(β-CD) were studied by NMR diffusion measurements, 1H-1H ROESY and solid-state high-resolution 13C NMR spectroscopy. Both α-CD and β-CD are found to be able to form inclusion-complex with α-NAA. The complex formed by β-CD and α-NAA are more stable than that formed by α-CD and α-NAA, due to the effect of cavity size. The association constant of β-CD/α-NAA complex was calculated from the self-diffusion coefficients of α-NAA. The application of β-CD/α-NAA system in drug release was discussed.

Key words: NMR; ROESY; 13C CP/MAS; Self-diffusion coefficient; Inclusion complex

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