高等学校化学学报

高等学校化学学报 ›› 1999, Vol. 20 ›› Issue (S1): 162.

• Electroanalytical Chemistry • 上一篇    下一篇

Determination of Trace Metoclopramide by Anodic Stripping Voltammetry with Nafion Modified Glassy Carbon Electrode

WANG Zhen-Hni, ZHANG Hong-Zhong, ZhOU Shu-Ping, DONG Wen-Ju, ZHANG Xiu-Ying   

  1. Department of Chemistry, Henan Normal University, Xinxiang 453002, P. R. China
  • 出版日期:1999-12-31 发布日期:1999-12-31

Determination of Trace Metoclopramide by Anodic Stripping Voltammetry with Nafion Modified Glassy Carbon Electrode

WANG Zhen-Hni, ZHANG Hong-Zhong, ZhOU Shu-Ping, DONG Wen-Ju, ZHANG Xiu-Ying   

  1. Department of Chemistry, Henan Normal University, Xinxiang 453002, P. R. China
  • Online:1999-12-31 Published:1999-12-31

PDF (PC)

被引次数

91

摘要：

Metoclopramide[monohydrate of 4-amino-5-chloro-N-(2-diethylaminoethyl)-2-methoxybenzamide hydrochloride,MCP] is the active ingredient of many pharmaceutical preparations concermed with the modification of digestive behaviour. Studies describing the pharmacokinetics and disposition of MCP in humans indicated that the drug is rapidly and well absorbed following oral administration with peak time at about one hour. However,the bioavailability of MCP is very variable (32-97%) and this out of considerable inter-individual variation in metabolism. The difference in the bioavailability of oral MCP in different subjects has potential clinical importance since its antiemetic effect and central nervous system adverse effects correlate with the plasma concentrations. Therefore,the measurement of MCP plasma concentration is essential to optimize therapy and to avoid toxic concentrations.

Abstract:

Metoclopramide[monohydrate of 4-amino-5-chloro-N-(2-diethylaminoethyl)-2-methoxybenzamide hydrochloride,MCP] is the active ingredient of many pharmaceutical preparations concermed with the modification of digestive behaviour. Studies describing the pharmacokinetics and disposition of MCP in humans indicated that the drug is rapidly and well absorbed following oral administration with peak time at about one hour. However,the bioavailability of MCP is very variable (32-97%) and this out of considerable inter-individual variation in metabolism. The difference in the bioavailability of oral MCP in different subjects has potential clinical importance since its antiemetic effect and central nervous system adverse effects correlate with the plasma concentrations. Therefore,the measurement of MCP plasma concentration is essential to optimize therapy and to avoid toxic concentrations.

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