高等学校化学学报 ›› 2012, Vol. 33 ›› Issue (12): 2688.doi: 10.7503/cjcu20120461

• 有机化学 • 上一篇    下一篇

苗药双肾草中一个新的联苄类化合物

刘育辰1,2, 刘刚1, 张宪民2, 陈剑超2, 邱明华2, 邱德文1   

  1. 1. 贵阳中医学院药学系, 贵阳 550002;
    2. 中国科学院昆明植物研究所, 植物化学与西部植物资源持续利用国家重点实验室, 昆明 650204
  • 收稿日期:2012-05-11 出版日期:2012-12-10 发布日期:2012-11-20
  • 通讯作者: 邱明华,男,博士,研究员,博士生导师,主要从事天然有机化学和植物资源开发研究.E-mail:qiuminghua@mail.kib.ac.cn E-mail:qiuminghua@mail.kib.ac.cn
  • 基金资助:

    中国科学院"科技之黔工程"项目(批准号: 黔-01-2005-01)资助.

New Bibenzyl Derivative from Miao Medicine Herminium bulleyi

LIU Yu-Chen1,2, LIU Gang1, ZHANG Xian-Min2, CHEN Jian-Chao2, QIU Ming-Hua2, QIU De-Wen1   

  1. 1. Department of Pharmacy, Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China;
    2. State Key laboratory of Phytochemistry and Plant Resources in West China, Kunming Institue of Botany, Chinese Academy of Sciences, Kunming 650204, China
  • Received:2012-05-11 Online:2012-12-10 Published:2012-11-20
  • Contact: hua mingqiu E-mail:qiuminghua@mail.kib.ac.cn

摘要:

从苗药双肾草[Herminium bulleyi(Rolfe) Tang et Wang]块茎的甲醇提取物中分离鉴定了6个化合物, 其中化合物6是新化合物, 命名为双肾草素, 经NMR等波谱解析, 确定其结构为2,2-dimethyl-5-methoxy-7-[2-(3″-hydroxyphenyl)ethyl]chromene, 其余化合物均为首次从该植物中分离得到.

关键词: 苗药, 双肾草, 联苄类化合物

Abstract:

Herminium bulleyi(Rolfe) Tang et Wang is a medicinal herb used to treat common disease such as impotent, premature ejaculation and spematorrhea by Miao in China. Despite of the widespread medicinal uses in Miao area, there is no phytochemical research on it. We had investigated its chemical consitituents for further sustainable utilization. In this work, six compounds were isolated and purification by silica gel, Sephadex LH-20 and RP-C18 gel column chromatography from methyl alcohol extract of the tubers of Herminium bulleyi. Their structures were elucidated on the basis of spectroscopic evidence, particularly by two-dimensional NMR spectroscopic analysis. And they were identified as palmitic acid(1), 9,19-cyclo-9β-lanost-24-en-3-ol(2), β-sitosterol(3), glycerol monopalmitate(4), monostearin(5) and shuangshencaosu 2,2-dimethyl-5-methoxy-7-[2-(3″-hydroxyphenyl)ethyl]chromene(6). Among them, compound 6 is a new compound, the others are firstly isolated from this species.

Key words: Miao medicine, Herminium bulleyi, Bibenzyl compound

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