高等学校化学学报 ›› 1984, Vol. 5 ›› Issue (5): 686.

• 研究简报 • 上一篇    下一篇

四级铵基取代羧酸转化为酰氯的探试

马庆一, 李良助, 张滂   

  1. 北京大学化学系
  • 收稿日期:1983-05-18 出版日期:1984-10-24 发布日期:1984-10-24

Attempts of Converting Simple Carboxylic Acids Bearing A Quaternary Ammonium Chlorido Group into Their Acid Chlorides

Ma Qinyi, Li Liangzhu, Zhang Pang   

  1. Department of Chemistry, Peking University, Beijing
  • Received:1983-05-18 Online:1984-10-24 Published:1984-10-24

摘要: 绝大多数Schotten-Baumann酰化[1]在两相间发生,为探究在单相水介质中合成酰胺的效率,我们企图对几个典型的羧酸引入四级铵基,以制备结晶的水溶性酰氯.

Abstract: Of pyridinium chloridoacetic acid(1), N, N-dimethylanilinium chloridoacetic acid(2), 6-trimethylammonium chloridocaproic acid(3),.p-trimeth-ylammonium chloridobenzoic acid(4),and triethylammonium chloridoacetic acid(5),only the last one was transformed by treatment with thionyl chloride into its acid chloride(6), which was identified by converting to p-bromo-, p-iodo-,and 3,4-dimethylanilides.It seems that simple carboxylic acids bearing a quaternary ammonium chloride group are not easily transformed into their acid chlorides probably owing to their insolubility in both chlorinating agents and organic solvents.

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