高等学校化学学报

高等学校化学学报 ›› 1986, Vol. 7 ›› Issue (4): 287.

• 研究论文 •    下一篇

顺铂与DNA结合方式—N7、N1链内交联模型化合物的合成和表征

曲筠, 唐雯霞, 戴安邦   

  1. 南京大学配位化学研究所
  • 收稿日期:1985-03-25 出版日期:1986-04-24 发布日期:1986-04-24

Synthesis and Characterization of N7,N1 Cross-linkage Model Compound of Platinum and Guanosine

Qu Yun, Tang Wenxia, Dai Anbang   

  1. Coordinction Chemistry Research Institute of Nanjing University, Nanjing
  • Received:1985-03-25 Online:1986-04-24 Published:1986-04-24

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摘要： 以摩尔比为1:1的[Pt(NH3)2(H2O)2]·(NO3)2与鸟苷反应,经过重结晶,得到了1:1的纯化合物,通过摩尔电导、数均分子量、元素分析测定、13CNMR、紫外光谱的表征,确定化合物为[{Pt(NH3)2}8(GuOH-1)7(OH)2]·(NO3)7·8H2O。

Abstract: The title Pt-Guo compound was synthesized and isolated by the reaction between cis-CPt(NH3)2 (H2O)2]·(NO3)2 and guanosinc of mol ratio 1:1 in a neutral aqueous solution followed by careful purification with partial crystalization and rccrystallization from water at 0℃. The compound was characterized by elemental analysis, molecular weight determination, DTA, and 13C NMRspeclros-copy and its formula was found to be C{Pt(NH3)2}8(GuoH-1 )7(OH)2]·(NO3)7 · 8H2O.The isolation of the compound provides direct evidence for the intrastrand cross-linkage between Cisplatin and DNAthrough N7, N1 atoms of two adjacent guanines.

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