高等学校化学学报

高等学校化学学报 ›› 1987, Vol. 8 ›› Issue (4): 336.

• 论文 • 上一篇    下一篇

相转移催化不对称合成(Ⅰ)--相转移催化反应合成光学活性α-氨基酸

俞凌翀, 王非   

  1. 北京师范大学化学系
  • 收稿日期:1985-11-10 出版日期:1987-04-24 发布日期:1987-04-24

Asymmetric Induction Under Two-Phase Conditions (Ⅰ)--Asymmetric Induction in the Gabriel Reaction by Means of Two-Phase System-Synthesis of Optically Active Amino Acids

Vu Lingchong, Wang Fei   

  1. Department of Chemistry, Beijing Normal University, Beijing
  • Received:1985-11-10 Online:1987-04-24 Published:1987-04-24

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摘要： 在固液两相条件下用手性季铵盐为相转移催化剂,邻苯二甲酰亚胺钾与α-溴代羧酸酯反应,合成了十二个具有光学活性的α-(邻苯二甲酰亚胺基)羧酸酯,经肼解和水解,得到相应的光学活性α-氨基酸,光学纯度百分率为3.6-17.8%。

Abstract: Reaction of potassium phthalimide and ethyl α-bromocarboxylates under solid-liquid phase-transfer conditions, using chiral ammonium quaternary salts as phase transfer catalyst, affords twelve optically active 2-phthalimido-esters. The N-substituted phthalimide by hydrazinolysis, the resulting esters of amino acids can readily be hydrolyzed to the corresponding optically active amino acids with optical yield 3.6-17.8%.

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