高等学校化学学报

高等学校化学学报 ›› 1988, Vol. 9 ›› Issue (3): 307.

• 研究简报 • 上一篇    

N1-乙酰基-N3-邻甲苯甲酰基-5-氟脲嘧啶的晶体和分子结构

蒋安北1, 胡盛志1, 王义康2, 陈琦2   

  1. 1. 厦门大学化学系;
    2. 西安制药厂研究所
  • 收稿日期:1986-11-11 出版日期:1988-03-24 发布日期:1988-03-24

Crystal and Molecular Structure of N1-Acetyl-N3-O-Toluyl -5-Fluorouracii

Jiang Anbei1, Hu Shengzhi1, Wang Yikang2, Chen Qi2   

  1. 1. Xiamen University, Xiamen;
    2. Xi'an Pharmaceutical plant, Xi'an
  • Received:1986-11-11 Online:1988-03-24 Published:1988-03-24

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摘要： 5-氟脲嘧啶(5-FU)和N1(2-四氰呋喃)-5-氟脲嘧啶(FT-207.2)在肿瘤的临床实验上,引起了人们极大的兴趣和得到广泛的应用,但它们具有毒性大和对肿瘤的免疫抑制作用,因此,为提高疗效,降低毒性的5-FU衍生物的开发,引起了人们的关心.

Abstract: The crystal of the title compound belongs to monoclinic system.Space group P21/n, with dimensions.α = 15.795(4), b = 8.367(3), c = 10.720(4) Å,β = 104.98(3)o, V= 1368.6Å3,Z= 4, Dc = 1,409gcm-3, μ(MoKα) = 1.067cm-1, λ(MoKα) = 0.71069 Å.The final R/Rw = 0.045/0.039 for 235 parameters and 1898 observed refledions were Treasured with an FNRAF-NONIUS CAD-4 diff-ractometer using MoKα radiation at 293K.The molecule consists of fluorouracil moiety and o-toluyl group which are virtually perpendicular to each other.The present paper deals with brief discussion of the structural features which may be responsible for its special antitumor activity for the title compound.

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