高等学校化学学报 ›› 1989, Vol. 10 ›› Issue (5): 528.

• 研究简报 • 上一篇    下一篇

无味红霉素的极谱研究及应用

胡荫华, 张咏惠, 邢小放   

  1. 西北大学化学系
  • 收稿日期:1987-07-17 出版日期:1989-05-24 发布日期:1989-05-24
  • 通讯作者: 张咏惠

Polarographic Studies of Erythromycin Estolate and Its Application

Hu Yinhua, Zhang Yonghui, Xing Xiaofang   

  1. Department of Chemistry, Northwest University, Xian
  • Received:1987-07-17 Online:1989-05-24 Published:1989-05-24

摘要: 无味红霉素是一种广谱临床抗生素,其分析方法已见报道的有薄层分离、生物自显影法[1]和分光光度法[2.3]。本文首次研究了无味红霉素的单扫极谱测定法,方法灵敏度可达0.05μg/mL,应用于血清和片剂分析,结果令人满意。并对极谱波性质作了初步探讨。

关键词: 无味红霉素, 极谱

Abstract: Asingle-sweep polarographic method is first presented here for the quantitative analysis of erythromycin estolate(I). Using 4 raol/L H2SO4 as the supporting electrolyte, the peak potential is -0.57 V(vs SCE). Alinear dependence between the concentration and the peak height is observed over the 0.05~10μg/mLrange with the correlation coefficient 0.9984. The adsorptive character of Iat Hg electrode is discussed. Applicability of the title method to direct measurement of Iin tablets and serum is assessed.

Key words: Erythromycin estolate, Polarographic

TrendMD: