高等学校化学学报

高等学校化学学报 ›› 1992, Vol. 13 ›› Issue (5): 658.

• 论文 • 上一篇    下一篇

湖北贝母属植物化学成分的研究(Ⅻ)——鄂贝新的X射线衍射测定立体结构

吴继洲1, 谌了容2, 罗保生2   

  1. 1. 同济医科大学药学系, 武汉, 430030;
    2. 武汉大学分析测试中心
  • 收稿日期:1991-05-21 出版日期:1992-05-24 发布日期:1992-05-24
  • 通讯作者: 吴继洲

Studies on Chemical Constituents of Fritillaria in Hubei(Ⅻ)--X-Ray Determination of Stereo-Structure of Ebeiensine

WU Ji-zhou1, SHENG Liao-rong2, LUO Bao-sheng2   

  1. 1. Department of Pharmacy, Tongji Medical University, Wuhan, 430030;
    2. Centre of Analysis and Determination, Wuhan University
  • Received:1991-05-21 Online:1992-05-24 Published:1992-05-24

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摘要： 从鄂北贝母和紫花鄂北贝母中分离出鄂贝新(ebeiensine),分子式为C27H41NO3·H2O,属正交晶系,空间群为P212121,晶胞参数a=0.6952(2)nm,b=1.5150(2)nm,c=2.5359(7)nm,Z=4,V=2.53260×10-27m3,有11-deoxo-5,6-dihydrojervanine杂环骨架,立体结构为5a,14a,20β-jervanine-3β-hydroxy-6-one,R=0.055。

关键词: 湖北贝母属, 鄂贝新, X射线衍射

Abstract: The ebeiensine was isolated from the bulb of Fritillaria ebeiensis G.D.Yu et G.Q.Ji and Fritillaria ,ebeiensis var.purpurea G. D. Yu et P. Li.The result of the complete X-ray structural analysis shows that ebeiensine with the molecular formula C27H41NO3·H2O, belongs to the rhombic system with space group P212121, and the lattice parameters are as follows- a=0.6952(2) nm, b=1.5150(2) nm, c=2.5359(7) nm, 7=2.53260×10-27 m3, Z=4, R=0.055.Ebeiensine has an 11-deoxo-5,6-dihydrojervanine heterocyclic skeleton and a stereochem-ical structure of 5a, 14α,20β-jervanine-3β-hydroxy-6-one.At the same time, C17—O—C23 was confirmed as β-configuration.

Key words: Fritillaria in Hubei, Ebeibeimu, X-Ray diffraction

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