高等学校化学学报

高等学校化学学报 ›› 2010, Vol. 31 ›› Issue (5): 982.

• 研究论文 • 上一篇    下一篇

用于疾病诊断的GdⅢ/量子点多模态成像探针的构建

张兵波1, 宫晓群2, 李卓权1, 郭方方1, 蔡少瑜5, 孔继烈5, 杨秋花2, 马浩2, 常津1,2, 时东陆1,3,4   

  1. 1. 同济大学先进材料与纳米生物医学研究院, 上海 200092;
    2. 天津大学材料学院纳米生物技术研究所, 天津 300072;
    3. 辛辛那提大学化学与材料工程系, 辛辛那提 45221-0012;
    4. 上海交通大学微纳研究院, 上海 200240; 5. 复旦大学化学系, 上海 200433
  • 收稿日期:2009-10-23 出版日期:2010-05-10 发布日期:2010-05-10
  • 通讯作者: 时东陆, 男, 博士, 教授, 主要从事纳米生物材料研究. E-mail: shid@ucmail.uc.edu
  • 基金资助:

    国家自然科学基金(批准号: 50873076)、国家“八六三”重点项目(批准号: 2007AA021808)、上海纳米专项(批准号: 0952nm04800, 0852nm03800)和同济大学青年优秀人才培养计划(批准号: 2009KJ072)资助.

Preparation of GdⅢ/Quantum Dots Multimodal Imaging Probes for Disease Diagnosis

ZHANG Bing-Bo1, GONG Xiao-Qun2, LI Zhuo-Quan1, GUO Fang-Fang1, CAI Shao-Yu5, KONG Ji-Lie5, YANG Qiu-Hua2, MA Hao2, CHANG Jin1,2, SHI Dong-Lu1,3,4*   

  1. 1. Institute for Advanced Materials and Nano Biomedicine, Tongji University, Shanghai, 200092 China;
    2. Institute of Nanobiotechnology, School of Materials Science & Engineering, Tianjin University, Tianjin 300072, China;
    3. Department of Chemical and Materials Engineering, University of Cincinnati, Cincinnati OH 45221-0012, USA;
    4. Research Institute of Micro/Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, China;
    5. Department of Chemistry, Fudan University, Shanghai 200433, China
  • Received:2009-10-23 Online:2010-05-10 Published:2010-05-10
  • Contact: SHI Dong-Lu. E-mail: shid@ucmail.uc.edu
  • Supported by:

    国家自然科学基金(批准号: 50873076)、国家“八六三”重点项目(批准号: 2007AA021808)、上海纳米专项(批准号: 0952nm04800, 0852nm03800)和同济大学青年优秀人才培养计划(批准号: 2009KJ072)资助.

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摘要：

结合核磁共振成像(MRI)和荧光成像技术, 以钆离子、近红外低毒量子点、二氧化硅和聚丙烯酸(PAA)等为原料, 采用一系列纳米载体自组装技术, 构建出MRI弛豫率/荧光效率高和生物相容性好的GdⅢ/量子点多模态纳米探针. 结果表明, 与未螯合GdⅢ的量子点纳米探针相比, GdⅢ/量子点多模态纳米探针具有更高的弛豫率; t1-加权MRI成像也证实了GdⅢ/量子点多模态纳米探针具有很好的阳性造影功效.

关键词: 多模态成像; 近红外量子点; 核磁共振成像

Abstract:

One of the major challenges in tumor research is early diagnosis in vivo. The current diagnostic methods, such as PET, MRI, and hematology tests, although effective in some aspects of tumor observations, are limited as a result of single functionality. Furthermore, the detection mechanism is often not compatible with the imaging system, making it difficult for accurate diagnosis. In this paper, MRI and fluorescence imaging were combined with several key contrast agents including quantum dots(QDs), gadolinium ion, silica, and poly(acrylic acid)(PAA) for high relaxation rate, strong fluorescent emission, and good biocompatibility, among which GdⅢ/QDs were utilized for effective multimodal nano-probes. The experimental results from this study indicate a higher relaxation rate of the GdⅢ/QDs multimodal nano-probes than that of silica-coated QDs without GdⅢ. The t1-weighted MRI analysis show that these GdⅢ/QDs based nano-probes can be potentially used for effective multimodal imaging agents.

Key words: Multimodal imaging; Near infrared quantum dots; Magnetic resonance image(MRI)

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