高等学校化学学报 ›› 2010, Vol. 31 ›› Issue (1): 84.

• 研究论文 • 上一篇    下一篇

西藏胡黄连化学成分的分离和鉴定

尹立子1, 欧阳萍1, 徐雪1, 周丽光1, 2, 王大成1, 邓旭明1   

  1. 1. 吉林大学畜牧兽医学院, 长春 130062;
    2. 吉林省五星动物保健药厂, 长春 130062
  • 收稿日期:2009-04-01 出版日期:2010-01-10 发布日期:2010-01-10
  • 通讯作者: 邓旭明, 男, 博士, 教授, 博士生导师, 从事中药活性成分的药理作用研究. E-mail: xumingdeng@jluhp.edu.cn
  • 基金资助:

    国家科技支撑计划(批准号: 200B6AD31B05, 2008BAD4B04-4)资助.

Isolation and Identification of a New Compound from the Roots of Picrorhiza Scrophulariiflora

YIN Li-Zi1, OUYANG Ping1, XU Xue1, ZHOU Li-Guang1,2, WANG Da-Cheng1, DENG Xu-Ming1*   

  1. 1. College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, China;
    2. Five-star Animal Health Pharmaceutical Factory of Jilin Province, Changchun 130062, China
  • Received:2009-04-01 Online:2010-01-10 Published:2010-01-10
  • Contact: DENG Xu-Ming. E-mail: xumingdeng@jluhp.edu.cn
  • Supported by:

    国家科技支撑计划(批准号: 200B6AD31B05, 2008BAD4B04-4)资助.

摘要:

从西藏胡黄连中分离和鉴定了4个化合物, 其中化合物1是新化合物, 命名为西藏胡黄连酚苷E(Scrophenoside E), 结构为(2-甲氧基-4-乙酰基)苯酚-3-β-D-吡喃葡萄糖基-6-O-(4-β-D-吡喃葡萄糖基)香草酰基-β-D-吡喃葡萄糖苷.

关键词: 西藏胡黄连; 苯乙醇苷; 西藏胡黄连酚苷E

Abstract:

Xizang Huhuanglian, the roots of Picrorhiza scrophulariiflora Pennell, is a traditional Chinese Medicine used to treat damp-heat dysentery, jaundice, indigestion, common fever, acute viral hepatitis, and steaming of bone. The scholars of domestic and foreign have studied on the pharmacological effects of the plant, and found that the plant will be one of the most effective preparation in protecting the liver. This plant is rich in terpenoids, iridoid glycosides, phenolic glycosides and phenylethanoid glycosides. These compounds of the plant were isolated via silica gel column, D101 macroporous column, Sephadex LH-20 column, ODS column chromatography and HPLC. The structures of these compounds were identified by spectroscopic methods(NMR, IR, UV and MS) and chemical methods. Four compounds from this plant were obtained. Their names are Scrophenoside E(1) [(6-(4-acetyl-2-methoxyphenoxy)-3,5-dihydroxy-4-(3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)tetrahydro-2H-pyran-2-yl)methyl-3-methoxy-4-(3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)benzoate], Coniferin(2), Arbutin(3) and Androsin(4). Scrophenoside E is a new compound. Coniferin, Arbutin and Androsin are three known compounds.

Key words: Picrorhiza scrophulariiflora Pennell; Phenylethanoid glycosides; Scrophenoside E

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