乙烯基桥联的8-羟基喹啉衍生物的合成、抗氧化活性及促进鼠骨髓间质干细胞增殖的研究

高等学校化学学报 ›› 2010, Vol. 31 ›› Issue (1): 74.

乙烯基桥联的8-羟基喹啉衍生物的合成、抗氧化活性及促进鼠骨髓间质干细胞增殖的研究

张培全1, 曾和平2

1. 广州医学院生物与化学实验中心, 广州 510182;
2. 华南理工大学化学科学学院功能分子研究所, 广州 510641

收稿日期:2009-04-07 出版日期:2010-01-10 发布日期:2010-01-10
通讯作者: 张培全, 男, 助理实验师, 主要从事生物有机化学研究. E-mail: pqzhang@yahoo.com.cn
基金资助:
国家自然科学基金(批准号: 20471020, 20671036)和广东省科技计划项目(批准号: 2006A10801002)资助.

Synthesis, Antioxidation Activity of Bridged Vinyl-8-hydroxyquinolin Derivative and Its Induction Proliferation of Mesenchymal Stem Cells

ZHANG Pei-Quan1*, ZENG He-Ping2

1. Laboratory Center of Biology and Chemistry, Guangzhou Medical College, Guangzhou 510182, China;
2. Institute of Functional Molecules, Faculty of Chemistry, South China University of Technology, Guangzhou 510641, China

Received:2009-04-07 Online:2010-01-10 Published:2010-01-10
Contact: ZHANG Pei-Quan. E-mail: pqzhang@yahoo.com.cn
Supported by:
国家自然科学基金(批准号: 20471020, 20671036)和广东省科技计划项目(批准号: 2006A10801002)资助.

摘要/Abstract

摘要：

设计合成了2-乙烯基取代的8-羟基喹啉衍生物(6), 用IR, UV-Vis, 1H NMR, MS和元素分析确认其结构; 利用二苯代苦味酰基自由基(DPPH·)法和噻唑蓝比色(MTT)法分别测定了目标产物的抗氧化活性及调控鼠骨髓间质干细胞(MSCs)增殖的作用. 结果表明, 目标产物有较强的抗氧化活性, 随着产物浓度的增加, 其抗氧化活性先增强后减弱; 在低浓度时对鼠骨髓间质干细胞有促进作用. 研究发现, 化合物6抗氧化活性的提高与其含量相关.

关键词: 8-羟基喹啉衍生物; 抗氧化活性; 骨髓间质干细胞

Abstract:

2-Vinyl-8-hydroxyquinolin derivative(6) was synthesized and characterized by IR, UV-Vis, 1H NMR, MS and elemental analysis. Meanwhile, the title compound was biologically evaluated by the MTT assay on the proliferation of rat mar-row-derived mesenchymal stem cells(rMSCs) and by the DPPH· method on the antioxidation activity. The results show that the title compound can induce the proliferation of mesenchymal stem cell compared with the control group under a low concentration condition and inhibitive effect on a higher concentration condition. The results also show that compound 6 has strong antioxidation activity. With concentration increasing, antioxidation activity is first increased and then decreased. It was found that the increasing antioxidant property of this protein depended quantitatively on the increase of its the compound 6 content.

Key words: 8-Hydroxyquinolin derivative; Antioxidation activity; Proliferation of mesenchymal stem cell

TrendMD:

张培全1, 曾和平2. 乙烯基桥联的8-羟基喹啉衍生物的合成、抗氧化活性及促进鼠骨髓间质干细胞增殖的研究. 高等学校化学学报, 2010, 31(1): 74.

ZHANG Pei-Quan1*, ZENG He-Ping2. Synthesis, Antioxidation Activity of Bridged Vinyl-8-hydroxyquinolin Derivative and Its Induction Proliferation of Mesenchymal Stem Cells. Chem. J. Chinese Universities, 2010, 31(1): 74.

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