新(4′-三氟甲基嘧啶基)-2-苯磺酰脲衍生物的合成及生物活性

高等学校化学学报 ›› 2010, Vol. 31 ›› Issue (1): 64.

新(4′-三氟甲基嘧啶基)-2-苯磺酰脲衍生物的合成及生物活性

王红学, 李芳, 许丽萍, 李永红, 王素华, 李正名

南开大学农药国家工程研究中心, 元素有机化学国家重点实验室, 天津 300071

收稿日期:2009-04-09 出版日期:2010-01-10 发布日期:2010-01-10
通讯作者: 李正名, 男, 教授, 博士生导师, 中国工程院院士, 主要从事有机化学和农药化学研究. E-mail: nkzml@vip.163.com

Synthesis and Biological Activity of New Trifloromethyl-pyrimidine Phenylsulfonylurea Derivatives

WANG Hong-Xue, LI Fang, XU Li-Ping, LI Yong-Hong, WANG Su-Hua, LI Zheng-Ming*

National Pesticide Engineering Research Center, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China

Received:2009-04-09 Online:2010-01-10 Published:2010-01-10
Contact: LI Zheng-Ming. E-mail: nkzml@vip.163.com

摘要/Abstract

摘要：

以单取代苯磺酰脲除草剂NK92825和NK94827为基础, 将三氟甲基引入嘧啶环中, 设计合成了17个新的4′-三氟甲基嘧啶苯磺酰脲化合物, 产物结构均经¹H NMR及元素分析确证. 目标化合物经盆栽试验, 结果表明, 部分化合物有较好的除草活性.

关键词: 磺酰脲; 三氟甲基嘧啶; 除草活性

Abstract:

Seventeen new sulfonylurea derivatives with trifloromethyl group in the pyrimidine ring were designed and synthesized, based on NK92825 and NK94827. Their structures were confirmed by ¹H NMR and elemental analysis. Preliminary herbicidal activities of these new sulfonylurea compounds were determined by pot bioassay experiments at dosage of 375 g/ha. The results show that some derivatives display good heribicidal activities.

Key words: Sulfonylurea; Trifloromethyl-pyrimidine; Herbicidal activity

TrendMD:

王红学, 李芳, 许丽萍, 李永红, 王素华, 李正名. 新(4′-三氟甲基嘧啶基)-2-苯磺酰脲衍生物的合成及生物活性. 高等学校化学学报, 2010, 31(1): 64.

WANG Hong-Xue, LI Fang, XU Li-Ping, LI Yong-Hong, WANG Su-Hua, LI Zheng-Ming*. Synthesis and Biological Activity of New Trifloromethyl-pyrimidine Phenylsulfonylurea Derivatives. Chem. J. Chinese Universities, 2010, 31(1): 64.

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