高等学校化学学报

高等学校化学学报 ›› 2009, Vol. 30 ›› Issue (11): 2123.

• 研究论文 • 上一篇    下一篇

光激发纳米TiO2对胃癌SGC-7901细胞的杀伤作用

夏春辉1,2, 于文学1, 王百齐3, 王玉2, 王璐2, 黄海涛2   

  1. 1. 吉林大学材料科学与工程学院, 长春 130012;
    2. 齐齐哈尔医学院药学系, 齐齐哈尔 161006;
    3. 天津医科大学公共卫生学院, 天津 300070
  • 收稿日期:2009-03-04 出版日期:2009-11-10 发布日期:2009-11-10
  • 通讯作者: 于文学, 男, 教授, 博士生导师, 主要从事功能材料制备与性质研究. E-mail: yuwenxue@jlu.edu.cn
  • 基金资助:

    黑龙江省自然科学基金(批准号: D2007-113, D2007-114)、黑龙江省普通高等学校骨干教师创新能力资助计划(批准号: 1055G066, 1154G01)和黑龙江省卫生厅科学技术项目(批准号: 2006-414)资助.

Damaging Effects of Photoexcited TiO2 Nanoparticles on Gastric Cancer SGC-7901 Cells

XIA Chun-Hui1,2, YU Wen-Xue1*, WANG Bai-Qi3, WANG Yu2, WANG Lu2, HUANG Hai-Tao2   

  1. 1. College of Materials Science and Engineering, Jilin University, Changchun 130012, China;
    2. Pharmacy Department, Qiqihaer Medical College, Qiqihaer 161006, China;
    3. School of Public Health, Tianjin Medical University, Tianjin 300070, China
  • Received:2009-03-04 Online:2009-11-10 Published:2009-11-10
  • Contact: YU Wen-Xue. E-mail: yuwenxue@jlu.edu.cn
  • Supported by:

    黑龙江省自然科学基金(批准号: D2007-113, D2007-114)、黑龙江省普通高等学校骨干教师创新能力资助计划(批准号: 1055G066, 1154G01)和黑龙江省卫生厅科学技术项目(批准号: 2006-414)资助.

PDF (PC)

摘要：

探讨了光激发纳米TiO2对胃癌SGC-7901细胞的杀伤作用, 考察了在不同纳米TiO2浓度及不同光照时间下纳米TiO2的抑瘤效果, 并探讨了抑瘤机制. 结果表明, 光激发纳米TiO2对胃癌SGC-7901细胞具有明显的抑制作用, 其过程类似一级反应的动力学规律; 当纳米TiO2浓度为300 μg/mL时, 对胃癌SGC-7901细胞表现出较强的杀伤效果, 其主要表现形式有两种, 即细胞坏死和细胞凋亡, 是由光激发条件下, 纳米TiO2表面产生的活性氧组分对肿瘤细胞的有效杀伤所致.

关键词: 纳米TiO2; 胃癌SGC-7901细胞; 光激发; 杀伤效应

Abstract:

Damaging effects of photoexcited TiO2 nanoparticles on gastric cancer SGC-7901 cells were investigated. The influences of nanosized TiO2 content, and irradiation time on cancer inhibition were systematically studied, and the inhibition mechanism was primarily discussed. The results demonstrate that photoexcited TiO2 nanoparticles exhibit good inhibition effects on gastric cancer SGC-7901 cells, and this process follows appro-ximately first-order reaction rule. While the concentration of TiO2 nanoparticles is about 300 μg/mL, the damaging effects are rather remarkable. In addition, the exhibition forms of gastric cancer SGC-7901 cells are apoptosis and necrosis in killing experiments. Taken together, damaging effects of photoexcited TiO2 nanoparticles on gastric cancer SGC-7901 cells might be attributed to the reactive oxygen species formed on the TiO2 nanoparticles surface.

Key words: TiO2 nanoparticle; Gastric cancer SGC-7901 cell; Photoexcitement; Damaging effect

TrendMD: