高等学校化学学报

高等学校化学学报

• 研究论文 • 上一篇    下一篇

云南美登木内生真菌Phomopsis sp. Lz42的化学成分

袁琳1,2, 马娟1, 王婷3, 李国红1, 沈月毛1, 赵沛基1   

    1. 中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室, 昆明 650204;
    2. 中国科学院研究生院, 北京 100049;
    3. 贵阳医学院药学院, 贵阳 550004
  • 收稿日期:2008-04-07 修回日期:1900-01-01 出版日期:2009-01-10 发布日期:2009-01-10
  • 通讯作者: 赵沛基

Chemical Constituents from Endophytic Phomopsis sp. Lz42 of Maytenus hookeri

YUAN Lin1,2, MA Juan1, WANG Ting3, LI Guo-Hong1, SHEN Yue-Mao1, ZHAO Pei-Ji1*   

    1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China;
    2. Graduate School of the Chinese Academy of Sciences, Beijing 100049, China;
    3. School of Pharmacy, Guiyang Medical University, Guiyang 550004, China
  • Received:2008-04-07 Revised:1900-01-01 Online:2009-01-10 Published:2009-01-10
  • Contact: ZHAO Pei-Ji

PDF (PC)

摘要： 从云南美登木内生真菌Phomopsis species Lz42的琼脂平板发酵物中分离得到2个倍半萜和5个麦角甾醇类化合物(1~7), 其中化合物1和2为新化合物. 应用波谱技术确定其结构为4-Deacetyl-10-oxo-dihydrobotrydial(1)和麦角甾-6,22-二烯-5α,8α-环二氧-3-甲酸酯(2).

关键词: 倍半萜, 麦角甾醇类, Phomopsis sp. Lz42, 内生真菌, 云南美登木

Abstract: Endophytes, commonly present in higher plants, are important sources of natural products with pharmaceutical potential. A new sesquiterpenoid, 4-deacetyl-10-oxo-dihydro-botrydial(1), and a new sterol, 22E,24R-5α,8α-epidioxyergosta-6,22-dien-3β-formate(2), were isolated from solid cultures of an endophytic fungal strain Phomopsis species Lz42, cultivated on Maytenus hookeri, together with five related known compounds, 4β-acetoxy-9β-10β-15α-trihydroxyprobotrydial(3), 22E,24R-5α,8α-epidioxyergosta-6,22-dien-3β-ol(4), ergosterol(5), 22E,24R-ergosta-7,22-diene-3β,5α,6β-triol(6) and 22E,24R-ergosta-7,22-diene-3β,5α,6β,9α-tetraol(7). Their structures were identified by extensive spectroscopic, experiments especially 2D-NMR.

Key words: Sesquiterpenoid, Sterol, Phomopsis sp. Lz42, Endophyte, Maytenus hookeri

中图分类号: 

TrendMD: