高等学校化学学报

高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (S1): 85.

• Analytical Sciences • 上一篇    下一篇

A Study on Pharmacokinetic of Norfloxacin by Second Derivation Spectrophotometry

LIN Xin-Hua1, LI Chun-Yan1, HUANG Jian-Fang2, YE Hua-Zheng2, CHEN Shao-Feng2   

  1. 1. Department of Chemistry, Fujian Medical University, Fuzhou 350004;
    2. Department of Chemistry, Fujian Health School, Fuzhou 350001
  • 出版日期:2000-12-31 发布日期:2000-12-31

A Study on Pharmacokinetic of Norfloxacin by Second Derivation Spectrophotometry

LIN Xin-Hua1, LI Chun-Yan1, HUANG Jian-Fang2, YE Hua-Zheng2, CHEN Shao-Feng2   

  1. 1. Department of Chemistry, Fujian Medical University, Fuzhou 350004;
    2. Department of Chemistry, Fujian Health School, Fuzhou 350001
  • Online:2000-12-31 Published:2000-12-31

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摘要：

Norfloxacin (NFX) was the third era Pyridopyrimidinic acid antibacterial medicament, which was in common used to cure the infection of uretbra and respiratory tract, gonorrhea, and bacterium enteritis. By metabolizing in body, 60% of NFX in original shape were excreted in urine, so Pharmacokinetic of NFX was studied by determining concentration of NFX in urine. Till now, the methods of determining concentration of NFX in urine, such as fluorescence Spectrophotometry (with blank urine as antitheses[1]), HPLC[2] and microorganism[3] had been adopted, whose operation was numerous and trivial.

Abstract:

Norfloxacin (NFX) was the third era Pyridopyrimidinic acid antibacterial medicament, which was in common used to cure the infection of uretbra and respiratory tract, gonorrhea, and bacterium enteritis. By metabolizing in body, 60% of NFX in original shape were excreted in urine, so Pharmacokinetic of NFX was studied by determining concentration of NFX in urine. Till now, the methods of determining concentration of NFX in urine, such as fluorescence Spectrophotometry (with blank urine as antitheses[1]), HPLC[2] and microorganism[3] had been adopted, whose operation was numerous and trivial.

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