高等学校化学学报

高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (S1): 84.

• Analytical Sciences • 上一篇    下一篇

Chiral Resolution of l, l'-Binaphthalene-2, 2'-Diol and its (-)-Menthyl Chloroformate derivatives by HPLC with Urea Derivative as Chiral Stationary Phase

RUAN Tuan-Ping1, CHEN An-Qi2, AO Xiao-Ping1, HUANG Pei-Qiang2, JIN Li-Ren2   

  1. 1. The Key Lab, of Anal Set of MOE;
    2. Dept, of Chem., Xiamen Univ., Xiamen 361005
  • 出版日期:2000-12-31 发布日期:2000-12-31
  • 基金资助:

    Project supported by the NSF of China.

Chiral Resolution of l, l'-Binaphthalene-2, 2'-Diol and its (-)-Menthyl Chloroformate derivatives by HPLC with Urea Derivative as Chiral Stationary Phase

RUAN Tuan-Ping1, CHEN An-Qi2, AO Xiao-Ping1, HUANG Pei-Qiang2, JIN Li-Ren2   

  1. 1. The Key Lab, of Anal Set of MOE;
    2. Dept, of Chem., Xiamen Univ., Xiamen 361005
  • Online:2000-12-31 Published:2000-12-31
  • Supported by:

    Project supported by the NSF of China.

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被引次数

1

摘要：

Optically pure l,1'-binaphthalene-2,2'-diols are very useful compounds for various application[1] such as catalyst ligands for asymmetric synthesis, the starting materials for other chiral binaphthyl catalysts and resolving agents for racemic compounds. Consequently, the preparation of optically pure l,l'-binaphthalene-2,2'-diols are of current interest Recently, new methods of resolution of racemic l,1'-binaphthalene-2,2'-diols utilizing (-)-(lR)-menthyl chloroformate as the derivatization agent have been developed[2,3]. To determine the optical purity of these 1,1'-binaphthalenes, it is necessary to develop a convenient and reliable method for the detection of each stereoisomers.

Abstract:

Optically pure l,1'-binaphthalene-2,2'-diols are very useful compounds for various application[1] such as catalyst ligands for asymmetric synthesis, the starting materials for other chiral binaphthyl catalysts and resolving agents for racemic compounds. Consequently, the preparation of optically pure l,l'-binaphthalene-2,2'-diols are of current interest Recently, new methods of resolution of racemic l,1'-binaphthalene-2,2'-diols utilizing (-)-(lR)-menthyl chloroformate as the derivatization agent have been developed[2,3]. To determine the optical purity of these 1,1'-binaphthalenes, it is necessary to develop a convenient and reliable method for the detection of each stereoisomers.

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