高等学校化学学报

高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (S1): 518.

• Synthetic Sciences • 上一篇    下一篇

Studies On the Development of a New Chiral 2-Pyrrolidinone Synthon

ZHENG Xiao, LIU Liang-Xian, HUANG Pei-Qiang   

  1. Department of Chemistry, Xiamen University, Xiamen 361005
  • 出版日期:2000-12-31 发布日期:2000-12-31

Studies On the Development of a New Chiral 2-Pyrrolidinone Synthon

ZHENG Xiao, LIU Liang-Xian, HUANG Pei-Qiang   

  1. Department of Chemistry, Xiamen University, Xiamen 361005
  • Online:2000-12-31 Published:2000-12-31

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摘要：

Previous results from this laboratory have showed that N,O-dibenzylated malimide 1 is a versatile intermediate for the asymmetric synthesis of pyrrolidines, 2-pyrrolidinons and β-hydroxy-γ-amino acids[1-4]. All the reactivities showed in synthon A have been exploited, in order to extend our studies on the (S)-malic acid-based synthetic methodology, we were interested to study the synthon B.To this end,sulfone 2 and 3,two the potential synthetic equivalent to synthon B, were prepared from malimide 1. Preliminary results showed that sulfone 2 indeed displayed the reactivity of synthon B.

Abstract:

Previous results from this laboratory have showed that N,O-dibenzylated malimide 1 is a versatile intermediate for the asymmetric synthesis of pyrrolidines, 2-pyrrolidinons and β-hydroxy-γ-amino acids[1-4]. All the reactivities showed in synthon A have been exploited, in order to extend our studies on the (S)-malic acid-based synthetic methodology, we were interested to study the synthon B.To this end,sulfone 2 and 3,two the potential synthetic equivalent to synthon B, were prepared from malimide 1. Preliminary results showed that sulfone 2 indeed displayed the reactivity of synthon B.

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