高等学校化学学报

高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (S1): 509.

• Synthetic Sciences • 上一篇    下一篇

Synthesis and Biological Activity of α-Substituted 1,2,3-Thiadiazole-4-Acetic Acid Derivatives

ZHAO Wei-Guang, LI Zheng-Ming, LIAO Lian-An   

  1. Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071
  • 出版日期:2000-12-31 发布日期:2000-12-31
  • 通讯作者: LI Zheng-Ming
  • 基金资助:

    Project (#29832050) supported by the National Natural Science Foundation of China.

Synthesis and Biological Activity of α-Substituted 1,2,3-Thiadiazole-4-Acetic Acid Derivatives

ZHAO Wei-Guang, LI Zheng-Ming, LIAO Lian-An   

  1. Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071
  • Online:2000-12-31 Published:2000-12-31
  • Contact: LI Zheng-Ming
  • Supported by:

    Project (#29832050) supported by the National Natural Science Foundation of China.

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摘要：

Compounds containing 1,2,3-thiodiazole ring were reported to posses fungicidal1, herbicidal2 and growth regulation properties3. For example, N-phenyl-N'-1,2,3-thiadizazol-5-yl-urea (Thidiazuron, Dropp) has been used as a cotton defoliant4, herbicide and was also found to exhibit cytokinin-like activity in bioassay systems. The compound was more effective than Zeatin5 and 6-BA6. Because the synthesis of 1,2,3-thiodiazole ring is difficult,compounds containing 1,2,3-thiadiazole ring are relatively seldom reported. Herein, we report the synthesis of a novel series of α-substituted-1,2,3-thiadiazole-4-acetic acid derivatives.

Abstract:

Compounds containing 1,2,3-thiodiazole ring were reported to posses fungicidal1, herbicidal2 and growth regulation properties3. For example, N-phenyl-N'-1,2,3-thiadizazol-5-yl-urea (Thidiazuron, Dropp) has been used as a cotton defoliant4, herbicide and was also found to exhibit cytokinin-like activity in bioassay systems. The compound was more effective than Zeatin5 and 6-BA6. Because the synthesis of 1,2,3-thiodiazole ring is difficult,compounds containing 1,2,3-thiadiazole ring are relatively seldom reported. Herein, we report the synthesis of a novel series of α-substituted-1,2,3-thiadiazole-4-acetic acid derivatives.

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