高等学校化学学报

高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (S1): 504.

• Synthetic Sciences • 上一篇    下一篇

An Asymmetric Synthesis of Isoindolinones

CHEN Ming-De, HUANG Li-Qiang, HUANG Pei-Qiang   

  1. Department of Chemistry, Xiamen University, Xiamen 361005
  • 出版日期:2000-12-31 发布日期:2000-12-31
  • 基金资助:

    This work was supported by the National Science Fund for Distinguished Young Investigator (29625204);the NSF of China (29832020);the Foundation for University Key Teacher by the Ministry of Education and Xiamen University.

An Asymmetric Synthesis of Isoindolinones

CHEN Ming-De, HUANG Li-Qiang, HUANG Pei-Qiang   

  1. Department of Chemistry, Xiamen University, Xiamen 361005
  • Online:2000-12-31 Published:2000-12-31
  • Supported by:

    This work was supported by the National Science Fund for Distinguished Young Investigator (29625204);the NSF of China (29832020);the Foundation for University Key Teacher by the Ministry of Education and Xiamen University.

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摘要：

Recently, the results from this laboratory showed that the reductive alkylation of protected (S)-malimide could be achieved in a high regio- and diastereoselective manner. The substituted 2-pyrrolidinones thus formed are versatile chiral building blocks which can be used in the asymmetric synthesis of pyrrolidines[1,2],2-pyrrolidinones[3,4] and β-hydroxy-γ-amino acids[5,6]. As an extension of this work, and in combination with the current interest in the synthesis of isoindolin-1-ones, a study on the asymmetric reductive alkylation of phthalimide derived from (R)-phenylglycinol was undertaken.

Abstract:

Recently, the results from this laboratory showed that the reductive alkylation of protected (S)-malimide could be achieved in a high regio- and diastereoselective manner. The substituted 2-pyrrolidinones thus formed are versatile chiral building blocks which can be used in the asymmetric synthesis of pyrrolidines[1,2],2-pyrrolidinones[3,4] and β-hydroxy-γ-amino acids[5,6]. As an extension of this work, and in combination with the current interest in the synthesis of isoindolin-1-ones, a study on the asymmetric reductive alkylation of phthalimide derived from (R)-phenylglycinol was undertaken.

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