高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (S1): 495.
• Synthetic Sciences • 上一篇 下一篇
GAO Zhu-Lin, YIN Cai-Xia, LIU Fu-Chu, ZHU Hong-You
GAO Zhu-Lin, YIN Cai-Xia, LIU Fu-Chu, ZHU Hong-You
摘要:
Frontalin, the pheromone of Dendroctonus Bark Beetles, was first isolated by Kinzer[1] from hindgut extracts of male western pine beetles. Its structure was determined as 1,5-dimethyl-6,8-dioxabicyclo[3.2.1] octane (1) by spectral analysis and was confirmed by the synthesis of its racemate[1,2]. On account of its structural novelty and economic value, this compound has been studied extensively [3-5]. But most of its synthetic methods required relatively longer steps or suffered from the inaccessibility of starting materials or reagents. Now, we report a convenient synthetic method for (±)-frontalin starting from easily available material, natural unsaturated aliphatic aicd, oleic acid. The synthesis is shown in scheme.
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