高等学校化学学报

高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (S1): 477.

• Synthetic Sciences • 上一篇    下一篇

Study on the Ring-opening of α-L-arabinopyranoside Benzylidene Acetals

WEI Xiao-Mei1, GAO Li-Ming2, CHENG Dong-Liang1, SHEN Zheng-Wu3   

  1. 1. Department of Chemistry, Lanzhou University, Lanzhou 730000;
    2. Department of Chemistry, Northwest Normal University, Lanzhou 730070;
    3. Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
  • 出版日期:2000-12-31 发布日期:2000-12-31

Study on the Ring-opening of α-L-arabinopyranoside Benzylidene Acetals

WEI Xiao-Mei1, GAO Li-Ming2, CHENG Dong-Liang1, SHEN Zheng-Wu3   

  1. 1. Department of Chemistry, Lanzhou University, Lanzhou 730000;
    2. Department of Chemistry, Northwest Normal University, Lanzhou 730070;
    3. Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
  • Online:2000-12-31 Published:2000-12-31

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摘要：

OSW-1 was isolated from the bulbs of Ornithogalum saundersiae by Satoshi Kubo of Japan in 1992,which is 100 times more potent than other anticancer agents available in clinical use,such as CTP and TAX. The oligosaccharides of OSW-1 is composed of 2-O-acetyl-α-L-arabinopyranoside and 2-O-4-methoxybenzoyl-β-D-xylopyranosyl by 1-3. We study on the Synthesis of the oligosaccharides of OSW-1. Now we suggest the possible pathway of 2-O-acetyl-α-L-arabinopyranoside, especially study on the ring-opening of its benzylidene acetals.

Abstract:

OSW-1 was isolated from the bulbs of Ornithogalum saundersiae by Satoshi Kubo of Japan in 1992,which is 100 times more potent than other anticancer agents available in clinical use,such as CTP and TAX. The oligosaccharides of OSW-1 is composed of 2-O-acetyl-α-L-arabinopyranoside and 2-O-4-methoxybenzoyl-β-D-xylopyranosyl by 1-3. We study on the Synthesis of the oligosaccharides of OSW-1. Now we suggest the possible pathway of 2-O-acetyl-α-L-arabinopyranoside, especially study on the ring-opening of its benzylidene acetals.

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