高等学校化学学报

高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (S1): 460.

• Synthetic Sciences • 上一篇    下一篇

Synthesis and Biological Activity of Pyrazolo[5,1-d] [1,2,3,5]-Tetrazine-4-ones

HU Fang-Zhong, ZOU Xiao-Mao, LI Yong-Hong, YANG Hua-Zheng   

  1. State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071
  • 出版日期:2000-12-31 发布日期:2000-12-31
  • 基金资助:

    Project supported by the National Natural Science of Foundation of China (No. 29832050) and Doctors' Special Funds of Ministry of Education.

Synthesis and Biological Activity of Pyrazolo[5,1-d] [1,2,3,5]-Tetrazine-4-ones

HU Fang-Zhong, ZOU Xiao-Mao, LI Yong-Hong, YANG Hua-Zheng   

  1. State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071
  • Online:2000-12-31 Published:2000-12-31
  • Supported by:

    Project supported by the National Natural Science of Foundation of China (No. 29832050) and Doctors' Special Funds of Ministry of Education.

PDF (PC)

摘要：

It is reported that benzo[1,2,3]-triazine-4-ones have widespread use, for instance, as diuretics, sedatives, tranquilizers and inflammation inhibitors and pyrazolo[1,5-a]-1,3,5-triazines are potent inhibitors of xanthine oxidase. So far,the herbicidal activities of above fused ring compounds and their analogues have not been studied. According to the principle of bioisotherism, pyrazolo[5,1-d] [1,2,3,5]-tetrazine-4-ones (2) have been developed and synthesized.

Abstract:

It is reported that benzo[1,2,3]-triazine-4-ones have widespread use, for instance, as diuretics, sedatives, tranquilizers and inflammation inhibitors and pyrazolo[1,5-a]-1,3,5-triazines are potent inhibitors of xanthine oxidase. So far,the herbicidal activities of above fused ring compounds and their analogues have not been studied. According to the principle of bioisotherism, pyrazolo[5,1-d] [1,2,3,5]-tetrazine-4-ones (2) have been developed and synthesized.

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