高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (S1): 447.
• Synthetic Sciences • 上一篇 下一篇
WU Xin-Yan1, ZHANG Jie1, ZHOU Qi-Lin2
WU Xin-Yan1, ZHANG Jie1, ZHOU Qi-Lin2
摘要:
Despite phase transfer catalysis (PTC) is an important and useful method in organic synthesis, asymmetric synthesis using chiral phase-transfer catalyst has not been well documented and limited number of chiral phase-transfer catalyst have been developed[1].In 1989,O'Donnell published his pioneering work in the asymmetric synthesis of α-amino acids by enantioselective alkylation of a prochiral protected glycine derivative using chiral phase-transfer catalyst[2]. Since then, several groups reported their improvements on enantioselectivity and applicability on this useful synthetic reaction[3,4]. However, almost all of the chiral phase-transfer catalysts reported so far are the derivatives of cinchona[5]. In this presentation, we wish to describe the design and synthesis of a new type of chiral phase-transfer catalyst based on the camphor and its application in asymmetric alkylation of tert-bntyl glycinate-benzophenone Schiff base.
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