高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (S1): 439.
• Synthetic Sciences • 上一篇 下一篇
WANG Guang-Xing, IGUCHI Satoru, HIRAMA Masahiro
WANG Guang-Xing, IGUCHI Satoru, HIRAMA Masahiro
摘要:
The chromophores of enediyne chromoprotein anticancer antibiotics have attracted a lot of efforts towards the total synthesis. Very recently, Myers group[1] reported the first synthesis of neocarzinostatin chromophore 1. The key point of our approach for the total synthesis of this compound is to construct the highly strained and unstable bicyclic[7.3.0]epoxyenediyne core at the late stage of synthesis using an intramolecular acetylide aldehyde ring closure. The proposed approach is illustrated retrosynthetically as follows (Scheme).
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