高等学校化学学报

高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (S1): 155.

• Chemistry in Life Sciences • 上一篇    下一篇

The Effect of Chemical Structure on the DNA Binding Behavior of Tricyclic Heteroaromatic Ligands

WANG Xue-Mei, LI Yao, JIANG Xian-Hun   

  1. 1. The State Key Lab of Coordination Chem., Nanjing University, Nanjing 210093;
    2. National Lab of Molecular and Biomolecular Electronics, Southeast University, Nanjing 210096
  • 出版日期:2000-12-31 发布日期:2000-12-31
  • 基金资助:

    Supported by Visiting Scholar Foundation of Key Lab in University and the Scientific Research Foundation for Returned Overseas Chinese Scholars, The Ministry of Education of China.

The Effect of Chemical Structure on the DNA Binding Behavior of Tricyclic Heteroaromatic Ligands

WANG Xue-Mei, LI Yao, JIANG Xian-Hun   

  1. 1. The State Key Lab of Coordination Chem., Nanjing University, Nanjing 210093;
    2. National Lab of Molecular and Biomolecular Electronics, Southeast University, Nanjing 210096
  • Online:2000-12-31 Published:2000-12-31
  • Supported by:

    Supported by Visiting Scholar Foundation of Key Lab in University and the Scientific Research Foundation for Returned Overseas Chinese Scholars, The Ministry of Education of China.

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摘要：

It is well-known that small organic ligands can bind to the double-stranded nucleic acids by three modes, i.e.s grooving binding, intercalation, and electrostatic binding. Usually, intercalation of the ligands into the double helix involves the insertion of a planar atomatic cation into base stack of the helix, while groove binding of small molecules is pertaining to the docking of thin ribbon-like molecules in the minor groove of the helix. In both cases, electrostatic and hydrophobic interactions can afford additional stabilization for the binding.

Abstract:

It is well-known that small organic ligands can bind to the double-stranded nucleic acids by three modes, i.e.s grooving binding, intercalation, and electrostatic binding. Usually, intercalation of the ligands into the double helix involves the insertion of a planar atomatic cation into base stack of the helix, while groove binding of small molecules is pertaining to the docking of thin ribbon-like molecules in the minor groove of the helix. In both cases, electrostatic and hydrophobic interactions can afford additional stabilization for the binding.

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