高等学校化学学报

高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (S1): 154.

• Chemistry in Life Sciences • 上一篇    下一篇

Study on the Interaction of a New Antitumor Drug with DNA

WANG Xue-Mei1,2, LI Yao2, GONG Sheng-Jin2   

  1. 1. The State Key Lab of Coordination Chem., Nanjing University, Nanjing 210093;
    2. National Lab of Molecular and Biomolecular Electronics, Southeast University, Nanjing 210096
  • 出版日期:2000-12-31 发布日期:2000-12-31
  • 基金资助:

    Supported by Visiting Scholar Foundation of Key Lab in University and Chinese Education Foundation for Excellent Young Teachers as well as the Science & Technology Foundation of Jiangsu province (BJ99011).

Study on the Interaction of a New Antitumor Drug with DNA

WANG Xue-Mei1,2, LI Yao2, GONG Sheng-Jin2   

  1. 1. The State Key Lab of Coordination Chem., Nanjing University, Nanjing 210093;
    2. National Lab of Molecular and Biomolecular Electronics, Southeast University, Nanjing 210096
  • Online:2000-12-31 Published:2000-12-31
  • Supported by:

    Supported by Visiting Scholar Foundation of Key Lab in University and Chinese Education Foundation for Excellent Young Teachers as well as the Science & Technology Foundation of Jiangsu province (BJ99011).

PDF (PC)

被引次数

4

摘要：

Binding studies of small molecules with nucleic acids can not only provide new insight into biologically important non-covalent binding mechanisms but also afford a molecular basis to understand the interaction and sequence recognition by promising drugs targeted to DNA. A series of the investigation of the binding of some natural antibiotics, metal complexes and other heterocyclic cations is valuable for the rational design of new antiviral and antitumor agents for clinical use.

Abstract:

Binding studies of small molecules with nucleic acids can not only provide new insight into biologically important non-covalent binding mechanisms but also afford a molecular basis to understand the interaction and sequence recognition by promising drugs targeted to DNA. A series of the investigation of the binding of some natural antibiotics, metal complexes and other heterocyclic cations is valuable for the rational design of new antiviral and antitumor agents for clinical use.

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