高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (S1): 153.

• Chemistry in Life Sciences • 上一篇    下一篇

Synthesis and Theoretical Studies of Phosphoryl Amino Acid Analogue

TAN Bo, JU Yong, WANG Yu, QIN Dong-Yan, ZHAO Yu-Fen   

  1. Bioorganic Phosphorus Chemistry Laboratory, Department of Chemistry, Tsinghua University, Beijing 100084
  • 出版日期:2000-12-31 发布日期:2000-12-31

Synthesis and Theoretical Studies of Phosphoryl Amino Acid Analogue

TAN Bo, JU Yong, WANG Yu, QIN Dong-Yan, ZHAO Yu-Fen   

  1. Bioorganic Phosphorus Chemistry Laboratory, Department of Chemistry, Tsinghua University, Beijing 100084
  • Online:2000-12-31 Published:2000-12-31

摘要:

Phosphoryl amino acids and their analogues are continuing to be increasingly important as potential enzyme inhibitors, mechanistic probes for proteases[1,2]. Previously, a series of investigations on the structure-reactivity relationship about phosphoryl amino acids 1 had been carried out, the results showed that the co-participation of phosphoryl group, carboxyl group and residues of amino acids were essential and their biomimic reaction mechanisms were commonly through a penta-coordinate intramolecular mixed carboxylic-phosphoric anhydride intermediates[3].

Abstract:

Phosphoryl amino acids and their analogues are continuing to be increasingly important as potential enzyme inhibitors, mechanistic probes for proteases[1,2]. Previously, a series of investigations on the structure-reactivity relationship about phosphoryl amino acids 1 had been carried out, the results showed that the co-participation of phosphoryl group, carboxyl group and residues of amino acids were essential and their biomimic reaction mechanisms were commonly through a penta-coordinate intramolecular mixed carboxylic-phosphoric anhydride intermediates[3].

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